Artículo
Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease
Fecha de publicación:
12/2015
Editorial:
American Society for Microbiology
Revista:
Clinical and Vaccine Immunology
ISSN:
1556-6811
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
In 1967, infants and toddlers immunized with a formalin-inactivated vaccine against respiratory syncytial virus (RSV) experienced an enhanced form of RSV disease characterized by high fever, bronchopneumonia, and wheezing when they became infected with wild-type virus in the community. Hospitalizations were frequent, and two immunized toddlers died upon infection with wild-type RSV. The enhanced disease was initially characterized as a "peribronchiolar monocytic infiltration with some excess in eosinophils." Decades of research defined enhanced RSV disease (ERD) as the result of immunization with antigens not processed in the cytoplasm, resulting in a nonprotective antibody response and CD4(+) T helper priming in the absence of cytotoxic T lymphocytes. This response to vaccination led to a pathogenic Th2 memory response with eosinophil and immune complex deposition in the lungs after RSV infection. In recent years, the field of RSV experienced significant changes. Numerous vaccine candidates with novel designs and formulations are approaching clinical trials, defying our previous understanding of favorable parameters for ERD. This review provides a succinct analysis of these parameters and explores criteria for assessing the risk of ERD in new vaccine candidates.
Palabras clave:
RESPIRATORY SYNCYTIAL VIRUS
,
VACCINE
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Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Acosta, Patricio Leandro; Caballero, Mauricio Tomás; Polack, Fernando Pedro; Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease; American Society for Microbiology; Clinical and Vaccine Immunology; 12-2015; 1-7
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