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dc.contributor.author Acosta, Gimena
dc.contributor.author Silva, Raúl Alejandro
dc.contributor.author Gil, Raul Andres
dc.contributor.author Gomez, Roxana
dc.contributor.author Fernandez, Liliana Patricia
dc.date.available 2015-07-07T19:01:19Z
dc.date.issued 2013-02
dc.identifier.citation Acosta, Gimena; Silva, Raúl Alejandro; Gil, Raul Andres; Gomez, Roxana; Fernandez, Liliana Patricia; On-line enantioseparation of chlorpheniramine using <beta>-cyclodextrin and carbon nanotubes after multivariate optimization; Elsevier Science Bv; Talanta; 105; 2-2013; 167-172
dc.identifier.issn 0039-9140
dc.identifier.uri http://hdl.handle.net/11336/1083
dc.description.abstract Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm.
dc.format application/pdf
dc.language.iso eng
dc.publisher Elsevier Science Bv
dc.relation © 2012 Elsevier B.V. All rights reserved.
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject ON-LINE ENANTIORESOLUTION
dc.subject CARBON NANOTUBES
dc.subject B-CICLODEXTRIN
dc.subject FLOW INJECTION ANALYSIS
dc.subject MULTIVARIATE OPTIMIZATION
dc.subject.classification Química Analítica
dc.subject.classification Ciencias Químicas
dc.subject.classification CIENCIAS NATURALES Y EXACTAS
dc.title On-line enantioseparation of chlorpheniramine using <beta>-cyclodextrin and carbon nanotubes after multivariate optimization
dc.type info:eu-repo/semantics/article
dc.type info:ar-repo/semantics/artículo
dc.type info:eu-repo/semantics/publishedVersion
dc.date.updated 2016-03-30 10:35:44.97925-03
dc.journal.volume 105
dc.journal.pagination 167-172
dc.journal.pais Países Bajos
dc.journal.ciudad Amsterdam
dc.description.fil Fil: Acosta, Gimena. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - San Luis. Instituto de Quimica de San Luis; Argentina
dc.description.fil Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
dc.description.fil Fil: Gil, Raul Andres. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
dc.description.fil Fil: Gomez, Roxana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica;
dc.description.fil Fil: Fernandez, Liliana Patricia. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - San Luis. Instituto de Quimica de San Luis; Argentina
dc.journal.title Talanta
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.talanta.2012.11.045
dc.relation.alternativeid info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914012009897


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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)