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dc.contributor.author
Acosta, Gimena
dc.contributor.author
Silva, Raúl Alejandro
dc.contributor.author
Gil, Raul Andres
dc.contributor.author
Gomez, Roxana
dc.contributor.author
Fernandez, Liliana Patricia
dc.date.available
2015-07-07T19:01:19Z
dc.date.issued
2013-02
dc.identifier.citation
Acosta, Gimena; Silva, Raúl Alejandro; Gil, Raul Andres; Gomez, Roxana; Fernandez, Liliana Patricia; On-line enantioseparation of chlorpheniramine using <beta>-cyclodextrin and carbon nanotubes after multivariate optimization; Elsevier Science Bv; Talanta; 105; 2-2013; 167-172
dc.identifier.issn
0039-9140
dc.identifier.uri
http://hdl.handle.net/11336/1083
dc.description.abstract
Multiwalled carbon nanotubes are evaluated here as solid phase extraction (SPE) sorbent aiming to (±)-chlorpheniramine (CPA) enantioresolution with fluorimetric detection. β-cyclodextrin (CD) was added to the racemate and solutions with HCl and sodium dodecyl sulfate (SDS) in different proportions were assayed as eluents to achieve the separation between both enantiomers. The overall methodology involved a flow injection (FI) strategy enabling high sample throughput and low reagents consumption making it suitable for drug routine quality control. An adequate enantioresolution (2.08) with satisfactory responses for both (R)-CPA (peak area = 285) and (S)-CPA (peak area = 380) was achieved applying the proposed FI-SPE strategy under the optimized conditions [β-CD] = 1.0 mmol L-1, [HCl] = 1.0 x 10-2 mol L-1, [SDS] = 4.0 x 10-4 mol L-1 and eluent flow rate = 8.0 rpm.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Bv
dc.relation
© 2012 Elsevier B.V. All rights reserved.
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
On-Line Enantioresolution
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Carbon Nanotubes
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B-Ciclodextrin
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Flow Injection Analysis
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Multivariate Optimization
dc.subject.classification
Química Analítica
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Ciencias Químicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
On-line enantioseparation of chlorpheniramine using <beta>-cyclodextrin and carbon nanotubes after multivariate optimization
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-03-30 10:35:44.97925-03
dc.journal.volume
105
dc.journal.pagination
167-172
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Acosta, Gimena. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - San Luis. Instituto de Quimica de San Luis; Argentina
dc.description.fil
Fil: Silva, Raúl Alejandro. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
dc.description.fil
Fil: Gil, Raul Andres. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica; Argentina
dc.description.fil
Fil: Gomez, Roxana. Universidad Nacional de San Luis. Facultad de Quimica, Bioquimica y Farmacia. Departamento de Quimica. Area de Quimica Analitica;
dc.description.fil
Fil: Fernandez, Liliana Patricia. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - San Luis. Instituto de Quimica de San Luis; Argentina
dc.journal.title
Talanta
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.talanta.2012.11.045
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0039914012009897


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