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dc.contributor.author
Marini, Vanina Natalia  
dc.contributor.author
Laiolo, Jerónimo  
dc.contributor.author
Lozano, Natalia  
dc.contributor.author
Varengo, Haydee Teresita  
dc.date.available
2020-06-25T17:24:49Z  
dc.date.issued
2016-12  
dc.identifier.citation
Marini, Vanina Natalia; Laiolo, Jerónimo; Lozano, Natalia; Varengo, Haydee Teresita; Human toxocariosis: in vitro production of soluble mediators against Toxocara canis infection; Sociedad Chilena de Parasitología; Parasitologia Latinoamerica; 65; 3; 12-2016; 50-55  
dc.identifier.issn
0719-6326  
dc.identifier.uri
http://hdl.handle.net/11336/108239  
dc.description.abstract
Toxocara canis (T. canis) is an intestinal nematode that affects dogs. In humans, this geohelminth induces visceral larva migrans (VLM) syndrome, which is associated with eosinophilia, increased serum IgE and inflammation of the airways. In general, chronic nematode infections induce a polarized TH2 immune response.There are observations that the macrophages response to gastrointestinal nematodes in which the alternative activation pathway plays a more important role in resistance. However, whether or not Toxocara infectionsinduce alternative activation of human monocytes/macrophages is still a matter of debate. The objective of this study was to determine the pattern of IL12 and IL10 levels and nitric oxide (NO) production in vitro of human adherent cells against antigens from T. canis. For this purpose the in vitro cytokine production of adherent cells from healthy subjects was examined in response to stimulation with antigens from larval stage of T. canis.Cell culture supernatants were removed from antigen stimulated and unstimulated cultures after 24 hours, 15 and 20 days post infection and the concentration of IL-12, IL-10 and NO concentrations were determined.The results revealed high levels of IL-12 at 24 hours post stimulation. After that time, the concentration of this cytoquine declined to undetectable levels. IL-10 revealed a progressive increase from the 24 hours until the 20th day post stimulation. Conversely not detectable levels of NO were found during the study. Therefore,we concluded that during early T. canis infection, the activation and suppression of immune processes occur simultaneously and cytokines of adherent cells contribute to the regulation of the immune response.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Sociedad Chilena de Parasitología  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
TOXOCARA CANIS  
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NITRIC OXIDE  
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INTERLEUKIN  
dc.subject.classification
Parasitología  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
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Inmunología  
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Medicina Básica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Human toxocariosis: in vitro production of soluble mediators against Toxocara canis infection  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-06-16T13:14:55Z  
dc.journal.volume
65  
dc.journal.number
3  
dc.journal.pagination
50-55  
dc.journal.pais
Chile  
dc.description.fil
Fil: Marini, Vanina Natalia. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina  
dc.description.fil
Fil: Laiolo, Jerónimo. Area de Ciencias Agrarias, Ingeniería, Ciencias Biológicas y de la Salud de la Universidad Católica de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Lozano, Natalia. Clinica Universitaria Reina Fabiola; Argentina  
dc.description.fil
Fil: Varengo, Haydee Teresita. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina  
dc.journal.title
Parasitologia Latinoamerica  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://sociedadchilenaparasitologia.cl/revista-parasitologia-latinoamericana/