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dc.contributor.author
Reynoso, Marcos Adrian
dc.contributor.author
Daud, Adriana del Valle
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Belizán, María Melina Eleonora
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Sánchez Riera, Alvaro
dc.contributor.author
Vera, Nancy Roxana
dc.date.available
2020-06-25T11:02:25Z
dc.date.issued
2016-03
dc.identifier.citation
Reynoso, Marcos Adrian; Daud, Adriana del Valle; Belizán, María Melina Eleonora; Sánchez Riera, Alvaro; Vera, Nancy Roxana; Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits; International Journal of Pharmaceutical Sciences and Drug Research ; International Journal of Pharmaceutical Sciences and Drug Research ; 8; 2; 3-2016; 103-110
dc.identifier.issn
0975-248X
dc.identifier.uri
http://hdl.handle.net/11336/108176
dc.description.abstract
Ziziphus mistol Griseb. (Rhamnaceae), popularly known as ?mistol,? is widely distributed throughout Perú, Bolivia, Paraguay and Argentina. Its fruit is consumed in different forms in several argentinean communities. The present study was carried out to investigate the medicinal properties and safety of Ziziphus mistol (mistol) fruits ethanol and aqueous extracts and arrope. Antinociceptive activity was assessed using the formalin, acetic acid-induced writhing and tail-flick tests in rats. Anti-inflammatory effects were determinated through carrageenan induced edema test and cotton pellet-induced granuloma formation, in rats. The safety was evaluated with test of acute toxicity (48 hs) and sub-chronic toxicity (91 days).All extracts (1,000 mg / kg body weight) showed significant inhibition (P <0.05) in the pain and inflammation experimentally induced. In the acute toxicity study, a single dose of 4000 and 8000 mg/kg b.w., produced no mortality and no clinical signs of disease were observed after 48 h. In the sub-chronic toxicity study the extracts no caused significant visible signs of toxicity, nor mortality for 91 consecutive days of treatment. No significant differences were found in relative organ weights and hematological and biochemical parameters between the treated groups and the control groups. Aqueous extract and arrope of Z. mistol fruits could be good source of antinociceptive and anti-inflamatory agents because of its good activity and safety.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Journal of Pharmaceutical Sciences and Drug Research
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANTINOCICEPTIVE
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ANTIINFLAMMATORY
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ZIZIPHUS MISTOL
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SAFETY
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Otras Ciencias Biológicas
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Antinociceptive, anti-inflammatory effects and safety of Ziziphus mistol fruits
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-06-23T13:14:10Z
dc.journal.volume
8
dc.journal.number
2
dc.journal.pagination
103-110
dc.journal.pais
India
dc.journal.ciudad
Udaipur
dc.description.fil
Fil: Reynoso, Marcos Adrian. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
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Fil: Daud, Adriana del Valle. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
dc.description.fil
Fil: Belizán, María Melina Eleonora. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán; Argentina
dc.description.fil
Fil: Sánchez Riera, Alvaro. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Biología; Argentina
dc.description.fil
Fil: Vera, Nancy Roxana. Universidad Nacional de Tucuman. Facultad de Bioquímica, Química y Farmacia. Instituto de Farmacia. Cátedra de Farmacoquímica; Argentina
dc.journal.title
International Journal of Pharmaceutical Sciences and Drug Research
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://ijpsdr.com/index.php/ijpsdr/article/download/499/457
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