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dc.contributor.author
Ríos Lugo, María J.
dc.contributor.author
Jiménez Ortega, Vanesa
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Cano Barquilla, Pilar
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Fernández Mateos, Pilar
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Spinedi, Eduardo Julio
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dc.contributor.author
Cardinali, Daniel Pedro
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Esquifino, Ana I.
dc.date.available
2017-01-04T15:19:49Z
dc.date.issued
2015-03
dc.identifier.citation
Ríos Lugo, María J.; Jiménez Ortega, Vanesa; Cano Barquilla, Pilar; Fernández Mateos, Pilar; Spinedi, Eduardo Julio; et al.; Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 21; 3; 3-2015; 175-183
dc.identifier.uri
http://hdl.handle.net/11336/10801
dc.description.abstract
Background: Previous studies indicate that the administration of melatonin caused body weight and abdominal visceral fat reductions in rodent models of hyperadiposity. The objective of the present study performed in high-fat fed rats was to evaluate the activity of melatonin on gene expression of some medial basal hypothalamus (MBH) signals involved in feeding behavior regulation, including neuropeptide Y (NPY), proopiomelanocortin (POMC), prolactin-releasing peptide (PrRP), leptin- and insulinreceptors (R) and insulin-R substrate (IRS)-1 and -2. Blood levels of leptin and adiponectin were also measured.
Methods: Adult Wistar male rats were divided into four groups (n = 16 per group): (i) control diet (3% fat); (ii) highfat (35%) diet; (iii) high-fat diet+melatonin; (iv) control diet+melatonin. Rats had free access to high-fat or control chow and one of the following drinking solutions: (a) tap water; (b) 25 μg/mL of melatonin.
Results: After 10 weeks, the high-fat fed rats showed augmented MBH mRNA levels of NPY, leptin-R, PrRP, insulin-R, IRS-1 and IRS-2. The concomitant administration of melatonin counteracted this increase. Feeding of rats with a high-fat diet augmented expression of the MBH POMC gene through an effect insensitive to melatonin treatment. The augmented levels of circulating leptin and adiponectin seen in high-fat fed rats were counteracted by melatonin as was the augmented body weight: melatonin significantly attenuated a body weight increase in highfat fed rats without affecting chow or water consumption. Melatonin augmented plasma leptin and adiponectin in control rats.
Conclusions: The results indicate that an effect on gene expression of feeding behavior signals at the central nervous system (CNS) may complement a peripheral rise of the energy expenditure produced by melatonin to decrease body weight in high-fat fed rats.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
De Gruyter
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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Adiponectin
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Food Intake
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Gene Expression
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High-Fat Diet
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Leptin
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Medial Basal Hypothalamus
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Melatonin
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Neuropeptide Y
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Prolactin-Releasing Peptide
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Proopiomelanocortin
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Melatonin counteracts changes in hypothalamic gene expression of signals regulating feeding behavior in high-fat fed rats
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-12T14:29:44Z
dc.identifier.eissn
1868-1891
dc.journal.volume
21
dc.journal.number
3
dc.journal.pagination
175-183
dc.journal.pais
Alemania
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dc.journal.ciudad
Berlin
dc.description.fil
Fil: Ríos Lugo, María J.. Universidad Complutense de Madrid. Facultad de Medicina; España
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Fil: Jiménez Ortega, Vanesa. Universidad Complutense de Madrid. Facultad de Medicina; España
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Fil: Cano Barquilla, Pilar. Universidad Complutense de Madrid. Facultad de Medicina; España
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Fil: Fernández Mateos, Pilar. Universidad Complutense de Madrid. Facultad de Medicina; España
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Fil: Spinedi, Eduardo Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Cientifico Tecnológico la Plata. Centro de Endocrinologia Experimental y Aplicada (i); Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Médicas; Argentina
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Fil: Cardinali, Daniel Pedro. Pontificia Universidad Católica Argentina "Santa María de los Buenos Aires". Facultad de Ciencias Médicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Esquifino, Ana I.. Universidad Complutense de Madrid. Facultad de Medicina; España
dc.journal.title
Hormone Molecular Biology and Clinical Investigation
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1515/hmbci-2014-0041
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/hmbci.2015.21.issue-3/hmbci-2014-0041/hmbci-2014-0041.xml
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