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dc.contributor.author
Li, Chunshun  
dc.contributor.author
Sarotti, Ariel Marcelo  
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Wu, Xiaohua  
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Yang, Baojun  
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Turkson, James  
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Chen, Yongfei  
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Liu, Qingsong  
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Cao, Shugeng  
dc.date.available
2020-06-23T20:22:37Z  
dc.date.issued
2019-01  
dc.identifier.citation
Li, Chunshun; Sarotti, Ariel Marcelo; Wu, Xiaohua; Yang, Baojun; Turkson, James; et al.; An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431; Molecular Diversity Preservation International; Molecules; 24; 1; 1-2019; 1-11  
dc.identifier.issn
1420-3049  
dc.identifier.uri
http://hdl.handle.net/11336/108014  
dc.description.abstract
A new polyketide containing the benzoisoquinoline-9-one moiety, peyronetide A (1), and three other new derivatives peyronetides B–D (2–4), as well as one known compound (5) were purified from the cultured broth of the endophytic fungus Peyronellaea sp. FT431, which was isolated from the Hawaiian indigenous plant, Verbena sp. The structures of the new compounds were determined through the analysis of HRMS and NMR spectroscopic data. Compounds 1, 2, and 5 showed cytotoxic activities against TK-10 (human kidney adenocarcinoma cells), cisplatin sensitive A2780S (human ovarian carcinoma cells), and cisplatin resistant A2780CisR cell lines, with IC50 values between 6.7 to 29.2 µM.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Molecular Diversity Preservation International  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by/2.5/ar/  
dc.subject
ENDOPHYTIC FUNGI  
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PEYRONELLAEA  
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BENZOQUINOLINE  
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ANTIPROLIFERATIVE  
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Química Orgánica  
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Ciencias Químicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
An unusual benzoisoquinoline-9-one derivative and other related compounds with antiproliferative activity from Hawaiian endophytic fungus Peyronellaea sp. FT431  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-05-04T20:57:53Z  
dc.journal.volume
24  
dc.journal.number
1  
dc.journal.pagination
1-11  
dc.journal.pais
Suiza  
dc.journal.ciudad
Basilea  
dc.description.fil
Fil: Li, Chunshun. University of Hawaii; Estados Unidos  
dc.description.fil
Fil: Sarotti, Ariel Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Wu, Xiaohua. University of Hawaii; Estados Unidos  
dc.description.fil
Fil: Yang, Baojun. University of Hawaii; Estados Unidos  
dc.description.fil
Fil: Turkson, James. University of Hawaii; Estados Unidos  
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Fil: Chen, Yongfei. Chinese Academy of Sciences; República de China  
dc.description.fil
Fil: Liu, Qingsong. Chinese Academy of Sciences; República de China  
dc.description.fil
Fil: Cao, Shugeng. University of Hawaii; Estados Unidos  
dc.journal.title
Molecules  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337129/  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.3390/molecules24010196  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/24/1/196