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dc.contributor.author
Bianchini, Romina Marcela  
dc.contributor.author
Castellano, Patricia Margarita  
dc.contributor.author
Kaufman, Teodoro Saul  
dc.date.available
2020-06-23T20:18:51Z  
dc.date.issued
2012-04  
dc.identifier.citation
Bianchini, Romina Marcela; Castellano, Patricia Margarita; Kaufman, Teodoro Saul; Stress testing of valsartan: Development and validation of a high performance liquid chromatography stability-indicating assay; Taylor & Francis; Journal of Liquid Chromatography and Related Technologies; 35; 8; 4-2012; 1053-1069  
dc.identifier.issn
1082-6076  
dc.identifier.uri
http://hdl.handle.net/11336/108009  
dc.description.abstract
Stress testing studies were carried out on Valsartan (VAL) under hydrolytic (acidic, basic, and neutral), photolytic, oxidative, and thermal (in the solid state) conditions. Relevant degradation was observed when the drug was exposed to photolytic conditions, where two degradants (DP-1 and DP-2) were produced and when submitted to acid hydrolysis, which yielded one degradation product (DP-3). A high performance liquid chromatography method for the simultaneous determination of VAL and its degradation products was developed, optimized employing experimental design strategies, and validated, employing fully characterized standards of the degradation products. The results proved the stability-indicating property of the method.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Taylor & Francis  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
VALSARTAN  
dc.subject
STRESS TESTING  
dc.subject
STABILITY-INDICATING METHOD  
dc.subject.classification
Química Analítica  
dc.subject.classification
Ciencias Químicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Stress testing of valsartan: Development and validation of a high performance liquid chromatography stability-indicating assay  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-05-05T13:02:39Z  
dc.journal.volume
35  
dc.journal.number
8  
dc.journal.pagination
1053-1069  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Bianchini, Romina Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Castellano, Patricia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.description.fil
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina  
dc.journal.title
Journal of Liquid Chromatography and Related Technologies  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/10826076.2011.615094  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1080/10826076.2011.615094  

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