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dc.contributor.author
Yslas, Edith Inés
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dc.date.available
2020-06-23T19:11:09Z
dc.date.issued
2016-10
dc.identifier.citation
Yslas, Edith Inés; Nanomaterials toxicity and teratogenicity in aquatic environment using Rhinella arenarum model; Elsevier Ireland; Toxicology Letters; 259; 10-2016
dc.identifier.issn
0378-4274
dc.identifier.uri
http://hdl.handle.net/11336/107965
dc.description.abstract
Nanotechnology is growing at an exponential rate and will undoubtedly have both beneficial and toxicological impact and consequences on health and environment. Amphibians are being increasingly used for toxicity screening purposes due to their high sensitivity to physicochemical stress and useful indicators of freshwater contamination. Amphibians, with lifestage comprising embryos, tadpoles, and adults, have an extremely permeable skin, which makes them excellent indicators of environmental health. Rhinella arenarum is widely distributed in our region (Río Cuarto, Cordoba Province, Argentina). AMPHITOX is a set of customized toxicity test for acute, short term chronic, chronic andearly life stages of amphibian embryos of R. arenarum, which allow selecting the most appropriate exposure period and end points according to the toxicity of the sample and the purpose of the study.The main purpose of this study is to evaluate the susceptibility of embryos at 2-4 blastomeric stage (s2-s4) and larvaein premetamorphosis (stage 25) (AMPHITOX bio assay) to different concentrations of polyaniline (PANI) nanomaterials (nanofibersand nanoparticles). The susceptibility of R. arenarum larvae to PANI duringthe 25th stage of development was evaluated by exposing the larvae to different concentrations of each nanomaterial. On the otherhand, the teratogenic assay of different nanomaterials to embryos was carried out by observing the embryotoxic effects at continuousexposure from early blastula (S.2?S.4) during a 96 h period. These results demonstrated a stage-dependent susceptibility for PANI-nanomaterials. Early stage embryos are more sensitive than more mature embryos. The mayor toxicity perhaps it could be attributed to the minor size of the nanomaterials and its bioaccumulation. This in vivo model might serve to determine not only the PANI toxicity but also other nanomaterials, consequently this popular alternative organism can be extensively used as models in nanotoxicology.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Ireland
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
NANOTECHNOLOGY
dc.subject
TOXICITY TEST
dc.subject.classification
Otras Nanotecnología
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dc.subject.classification
Nanotecnología
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Nanomaterials toxicity and teratogenicity in aquatic environment using Rhinella arenarum model
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-06-16T13:11:35Z
dc.journal.volume
259
dc.journal.pais
Irlanda
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dc.description.fil
Fil: Yslas, Edith Inés. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Biología Molecular. Sección Química Biológica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Toxicology Letters
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://linkinghub.elsevier.com/retrieve/pii/S0378427416325243
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.toxlet.2016.07.161
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