Artículo
Controlled Thermoreversible Formation of Supramolecular Hydrogels Based on Poly(vinyl alcohol) and Natural Phenolic Compounds
Euti, Esteban
; Wolfel Sánchez, Alexis
; Picchio, Matías Luis
; Romero, Marcelo Ricardo
; Martinelli, Marisa
; Minari, Roque Javier
; Alvarez Igarzabal, Cecilia Ines
Fecha de publicación:
06/2019
Editorial:
Wiley VCH Verlag
Revista:
Macromolecular Rapid Communications
ISSN:
1022-1336
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Supramolecular hydrogels have promising applications in a wide variety of fields including 3D bioprinting, sensors and actuators, biomedicine and controlled drug delivery. This communication reports the facile reversible thermo-triggered formation of novel pH-responsive supramolecular hydrogels based on poly(vinyl alcohol) (PVA) bonded via dynamic H-bridge with small phenolic biomolecules. PVA and phenolic compounds form a clear solution when they are physically mixed in water at high temperature, but a fast gelation is produced at room temperature through multiple strong H-bonding interactions. The structure and type of functional groups of different phenolic molecules allow preparing hydrogels with tailor-made viscoelastic properties, controlled low phase transition temperature and pH-dependent swelling behavior. This combination makes these supramolecular networks very interesting candidates to be used in 3D bioprinting and topical drug delivery of thermolabile biomolecules.
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Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Articulos de INST.DE DES.TECNOL.PARA LA IND.QUIMICA (I)
Citación
Euti, Esteban; Wolfel Sánchez, Alexis; Picchio, Matías Luis; Romero, Marcelo Ricardo; Martinelli, Marisa; et al.; Controlled Thermoreversible Formation of Supramolecular Hydrogels Based on Poly(vinyl alcohol) and Natural Phenolic Compounds; Wiley VCH Verlag; Macromolecular Rapid Communications; 40; 18; 6-2019; 1900217-1/7
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