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dc.contributor.author
Martín Giménez, Virna Margarita  
dc.contributor.author
Inserra, Pablo Ignacio Felipe  
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Tajer, Carlos Daniel  
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Mariani, Javier  
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Ferder, Leon Fernando  
dc.contributor.author
Reiter, Russel  
dc.contributor.author
Manucha, Walter Ariel Fernando  
dc.date.available
2020-06-19T14:33:55Z  
dc.date.issued
2020-08  
dc.identifier.citation
Martín Giménez, Virna Margarita; Inserra, Pablo Ignacio Felipe; Tajer, Carlos Daniel; Mariani, Javier; Ferder, Leon Fernando; et al.; Lungs as Target of COVID-19 Infection: Protective Common Molecular Mechanisms of Vitamin D and Melatonin as a New Potential Synergistic Treatment; Pergamon-Elsevier Science Ltd; Life Sciences; 254; 8-2020  
dc.identifier.issn
0024-3205  
dc.identifier.uri
http://hdl.handle.net/11336/107715  
dc.description.abstract
COVID-19 pandemic has a high mortality rate and is affecting practically the entire world population. The leading cause of death is severe acute respiratory syndrome as a consequence of exacerbated inflammatory response accompanied by uncontrolled oxidative stress as well as the inflammatory reaction at the lung level. Until now, there is not a specific and definitive treatment for this pathology that worries the world population, especially the older adults who constitute the main risk group. In this context, it results in a particular interest in the evaluation of the efficacy of existing pharmacological agents that may be used for overcoming or attenuating the severity of this pulmonary complication that has ended the lives of many people worldwide. Vitamin D and melatonin could be good options for achieving this aim, taking into account that they have many shared underlying mechanisms that are able to modulate and control the immune adequately and oxidative response against COVID-19 infection, possibly even through a synergistic interaction. The renin-angiotensin system exaltation with consequent inflammatory response has a leading role in the physiopathology of COVID-19 infection; and it may be down-regulated by vitamin D and melatonin in many organs. Therefore, it is also essential to analyze this potential therapeutic association and their relation with RAS as part of this new approach.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Pergamon-Elsevier Science Ltd  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
COVID-19  
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RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM  
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VITAMIN D  
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MELATONIN  
dc.subject.classification
Enfermedades Infecciosas  
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Ciencias de la Salud  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Lungs as Target of COVID-19 Infection: Protective Common Molecular Mechanisms of Vitamin D and Melatonin as a New Potential Synergistic Treatment  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-06-19T13:20:40Z  
dc.journal.volume
254  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Amsterdam  
dc.description.fil
Fil: Martín Giménez, Virna Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Catolica de Cuyo. Facultad de Ciencias Quimicas y Tecnologicas; Argentina  
dc.description.fil
Fil: Inserra, Pablo Ignacio Felipe. Universidad de Maimónides; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
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Fil: Tajer, Carlos Daniel. Hospital El Cruce Néstor Kirchner; Argentina  
dc.description.fil
Fil: Mariani, Javier. Hospital El Cruce Néstor Kirchner; Argentina  
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Fil: Ferder, Leon Fernando. Universidad de Maimónides; Argentina  
dc.description.fil
Fil: Reiter, Russel. University Of Texas At San Antonio.; Estados Unidos  
dc.description.fil
Fil: Manucha, Walter Ariel Fernando. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas. Departamento de Patología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina  
dc.journal.title
Life Sciences  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0024320520305579  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.lfs.2020.117808