Repositorio Institucional
Repositorio Institucional
CONICET Digital
  • Inicio
  • EXPLORAR
    • AUTORES
    • DISCIPLINAS
    • COMUNIDADES
  • Estadísticas
  • Novedades
    • Noticias
    • Boletines
  • Ayuda
    • General
    • Datos de investigación
  • Acerca de
    • CONICET Digital
    • Equipo
    • Red Federal
  • Contacto
JavaScript is disabled for your browser. Some features of this site may not work without it.
  • INFORMACIÓN GENERAL
  • RESUMEN
  • ESTADISTICAS
 
Artículo

An invincible memory: what surname analysis tells us about history, health and population medical genetics in the Brazilian Northeast

Cardoso-dos-Santos, Augusto César; Ramallo, VirginiaIcon ; Zagonel-Oliveira, Marcelo; Veronez, Maurício Roberto; Navarro, Jose PabloIcon ; Monlleó, Isabella L.; Valiati, Victor Hugo; Dipierri, Jose Edgardo; Schuler-Faccini, Lavinia
Fecha de publicación: 03/2020
Editorial: Cambridge University Press
Revista: Journal Of Biosocial Science
ISSN: 0021-9320
e-ISSN: 1469-7599
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Otras Ciencias Sociales

Resumen

Several studies have shown that the Brazilian Northeast is a region with high rates of inbreeding as well as a high incidence of autosomal recessive diseases. The elaboration of public health policies focused on the epidemiological surveillance of congenital anomalies and rare genetic diseases in this region is urgently needed. However, the vast territory, socio-demographic heterogeneity, economic difficulties and low number of professionals with expertise in medical genetics make strategic planning a challenging task. Surnames can be compared to a genetic system with multiple neutral alleles and allow some approximation of population structure. Here, surname analysis of more than 37 million people was combined with health and socio-demographic indicators covering all 1794 municipalities of the nine states of the region. The data distribution showed a heterogeneous spatial pattern (Global Moran Index, GMI = 0.58; p < 0.001), with higher isonymy rates in the east of the region and the highest rates in the Quilombo dos Palmares region - the largest conglomerate of escaped slaves in Latin America. A positive correlation was found between the isonymy index and the frequency of live births with congenital anomalies (r=0.268; p < 0.001), and the two indicators were spatially correlated (GMI = 0.50; p < 0.001). With this approach, quantitative information on the genetic structure of the Brazilian Northeast population was obtained, which may represent an economical and useful tool for decision-making in the medical field.
Palabras clave: POPULATION STRUCTURE , POPULATION MEDICAL GENETICS , GEOGRAPHIC DISTRIBUTION
Ver el registro completo
 
Archivos asociados
Tamaño: 1.828Mb
Formato: PDF
.
Solicitar
Licencia
info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/107683
URL: https://www.cambridge.org/core/product/identifier/S0021932020000127/type/journal
DOI: http://dx.doi.org/10.1017/S0021932020000127
Colecciones
Articulos(IPCSH)
Articulos de INSTITUTO PATAGONICO DE CIENCIAS SOCIALES Y HUMANAS
Citación
Cardoso-dos-Santos, Augusto César; Ramallo, Virginia; Zagonel-Oliveira, Marcelo; Veronez, Maurício Roberto; Navarro, Jose Pablo; et al.; An invincible memory: what surname analysis tells us about history, health and population medical genetics in the Brazilian Northeast; Cambridge University Press; Journal Of Biosocial Science; 3-2020; 1-16
Compartir
Altmétricas
 

Enviar por e-mail
Separar cada destinatario (hasta 5) con punto y coma.
  • Facebook
  • X Conicet Digital
  • Instagram
  • YouTube
  • Sound Cloud
  • LinkedIn

Los contenidos del CONICET están licenciados bajo Creative Commons Reconocimiento 2.5 Argentina License

https://www.conicet.gov.ar/ - CONICET

Inicio

Explorar

  • Autores
  • Disciplinas
  • Comunidades

Estadísticas

Novedades

  • Noticias
  • Boletines

Ayuda

Acerca de

  • CONICET Digital
  • Equipo
  • Red Federal

Contacto

Godoy Cruz 2290 (C1425FQB) CABA – República Argentina – Tel: +5411 4899-5400 repositorio@conicet.gov.ar
TÉRMINOS Y CONDICIONES