Artículo
Progesterone and breast
Fecha de publicación:
04/2020
Editorial:
Bailliere Tindall
Revista:
Best Practice & Research In Clinical Obstetrics & Gynaecology
ISSN:
1521-6934
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Progesterone (Pg) is a pregnancy-related hormone that prepares the endometrium for the implantation of the fertilized zygote and suppresses myometrial contractility for the maintenance of pregnancy. At high concentrations, it acts as a natural immunosuppressant avoiding the rejection of a half allogeneic foetus. It is the precursor of many other related steroid hormones, but what is its role in the human breast? In this chapter, we will discuss some aspects related to Pg and its role in breast development and in the neoplastic disease. Understanding the mechanisms related to Pginduced effects in the normal and neoplastic mammary gland will light the way to exploit this hormone signalling pathway therapeutically. We will introduce some aspects of the effects of progestins in normal breast development, breast cancer risk and in neoplastic growth, and we will describe ongoing clinical trials in breast cancer using progestins or antiprogestins.
Palabras clave:
BREAST
,
BREAST CANCER
,
PROGESTERONE
,
PROGESTERONE RECEPTOR ISOFORMS
,
PROGESTINS
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Licencia
Identificadores
Colecciones
Articulos(IBYME)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Articulos de INST.DE BIOLOGIA Y MEDICINA EXPERIMENTAL (I)
Citación
Lamb, Caroline Ana; Fabris, Victoria Teresa; Lanari, Claudia Lee Malvina; Progesterone and breast; Bailliere Tindall; Best Practice & Research In Clinical Obstetrics & Gynaecology; 4-2020
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