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dc.contributor.author
Hapon, María Belén
dc.contributor.author
Hapon, María Vanda
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Persia, Andres
dc.contributor.author
Pochettino, Arístides Angel
dc.contributor.author
Lucero, Gabriela Susana
dc.contributor.author
Gamarra Lúques, C.
dc.date.available
2020-06-10T17:16:52Z
dc.date.issued
2014-12
dc.identifier.citation
Hapon, María Belén; Hapon, María Vanda; Persia, Andres; Pochettino, Arístides Angel; Lucero, Gabriela Susana; et al.; Aqueous Extract of Prosopis strombulifera (LAM) BENTH Induces Cytotoxic Effects against tumor Cell Lines without Systemic Alterations in BALB/c Mice; OMICS Publishing Group; Journal of Clinical Toxicology; 4; 6; 12-2014; 222-230
dc.identifier.issn
2161-0495
dc.identifier.uri
http://hdl.handle.net/11336/107190
dc.description.abstract
Prosopis strombulifera (Lam.) Benth. is a rhizomatous shrub native to the northern and central zones of Argentina. The analgesic and antibiotic properties of this plant had been demonstrated but there are no previous reports of its cytotoxic activity. The goal of this work was to analyze the cytotoxic activity of P. strombulifera against HCT-116 and MCF-7 cell lines, and to evaluate toxic systemic effects in BALB/c mice. Changes induced by the aqueous extract from leaves on tumoral cell lines were studied by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide) tetrazolium reduction assay, Trypan blue dye exclusion assay, optical microscopy, Western Blot analysis of PCNA and cPARP, LDH activity, Ames´ test and clonogenic survival. Oral sub-chronic toxicity was assessed on BALB/c mice at concentrations up to 150 mg/animal/day. Analyses included animal/organs weight; erythrocytes, leukocytes and platelets number; and serological determinations of glucose, ASAT, ALAT, urea and creatinine. Extract has induced cytotoxicity, affecting proliferation and viability in both cell lines in a dose and time-response manner. IC50 was 2.25 μg/ml and LC50 5.05 μg/ml in HCT-116, while values were 3.01 μg/ml and 7.52 μg/ml, respectively, in MCF-7. In both cell lines, the antiproliferative effect was confirmed by reduction of PCNA protein expression. When LC50 concentrations were used, extract-induced necrosis (evidenced by the increase in extracellular LDH activity), apoptosis (increased cPARP protein expression) and clonogenic survival diminution. Mutagenic activity of extract was caused at concentrations of 500 μg/ml (99 and 64-fold higher than HCT-116 and MCF-7 LC50 concentrations). Animal studies demonstrated that no significant toxicity was induced. In conclusion, this is the first report of P. strombulifera cytotoxic activity against tumoral cell lines. Sub-chronic extract administration did not cause deleterious effects in vivo. Altogether, the presented results make P. strombulifera a promising natural product for cancer research and treatment.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
OMICS Publishing Group
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Prosopis strombulifera
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Mutagenicity
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Cytotoxicity
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Natural products
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Antiproliferative
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Lethality
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Farmacología y Farmacia
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Aqueous Extract of Prosopis strombulifera (LAM) BENTH Induces Cytotoxic Effects against tumor Cell Lines without Systemic Alterations in BALB/c Mice
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-28T14:33:39Z
dc.journal.volume
4
dc.journal.number
6
dc.journal.pagination
222-230
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Los Angeles
dc.description.fil
Fil: Hapon, María Belén. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Hapon, María Vanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina
dc.description.fil
Fil: Persia, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.description.fil
Fil: Pochettino, Arístides Angel. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Laboratorio de Toxicología Experimental; Argentina
dc.description.fil
Fil: Lucero, Gabriela Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias; Argentina
dc.description.fil
Fil: Gamarra Lúques, C.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Catolica de Cuyo. Facultad de Ciencias Medicas. Instituto de Investigacion En Ciencias Biomedicas.; Argentina
dc.journal.title
Journal of Clinical Toxicology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://omicsonline.org/open-access/aqueous-extract-of-prosopis-strombulifera-lam-benth-induces-cytotoxic-2161-0495.1000-222.pdf
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4172/2161-0495.1000222
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