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dc.contributor.author
Mariojouls, Jorge
dc.contributor.author
Castro, Gonzalo
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Pisano, María Belén
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Barbero, Paula
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Fantilli, Anabella Clara
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Borda, Mariel Alejandra
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Canna, Fernando
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Barbás, Gabriela
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Ré, Viviana Elizabeth
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dc.date.available
2020-06-04T19:09:31Z
dc.date.issued
2019-05
dc.identifier.citation
Mariojouls, Jorge; Castro, Gonzalo; Pisano, María Belén; Barbero, Paula; Fantilli, Anabella Clara; et al.; Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak; Elsevier Science; Journal of Clinical Virology; 117; 5-2019; 49-53
dc.identifier.issn
1386-6532
dc.identifier.uri
http://hdl.handle.net/11336/106707
dc.description.abstract
During June-2016 - May-2017, several outbreaks of HA were recorded in Europe, especially described in MSM. In our area since July-2017, an increase of hepatitis A (HA) notification was reported. In order to understand the unusual increase of cases occurred in the central region of Argentina, the aim of this study was to describe, characterize and contextualize epidemiologically the HA outbreak occurred this area, until April 2018. Study designHA cases (positive anti-HAV IgM) obtained from the calendar week 29/2017 in which the first case of MSM was recognized were included in our study. HAV RNA detection and molecular characterization was performed from serum samples and / or stool by RT - PCR of VP1 / 2A genomic region (360bp).ResultsOf the 32 cases notified, 87.5% of them were unvaccinated men and 69.6% were MSM (mean age 31.9 years). All MSM associated HAV sequences were genotyped as IA, and clustered with the VRD 521-2016 strain, responsible of causing outbreaks mostly in MSM in Europe since mid-2016. As a consequence of the implementation of immunization in children, and the improvement in socio-economic, hygienic and sanitation factors, young adults are becoming increasingly susceptible to HAV infections. Here we add evidence in South America to the HA outbreaks described worldwide among young MSM, demonstrating the need to reinforce official policy of vaccination, in this group and adjust epidemiological surveillance, catch-up vaccination for adolescents, young adults and immuno suppressed patients.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HEPATITIS A
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HAV SURVEILLANCE
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OUTBREAK
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MSM
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GENOTYPING
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ARGENTINA
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Enfermedades Infecciosas
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Hepatitis A outbreak affecting men who have sex with men (MSM) in central Argentina, occurred in July 2017-April 2018, later than the European outbreak
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-06-02T13:44:09Z
dc.journal.volume
117
dc.journal.pagination
49-53
dc.journal.pais
Países Bajos
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dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Mariojouls, Jorge. Laboratorio Central de la Provincia de Cordoba; Argentina
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Fil: Castro, Gonzalo. Laboratorio Central de la Provincia de Cordoba; Argentina
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Fil: Pisano, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
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Fil: Barbero, Paula. Laboratorio Central de la Provincia de Cordoba; Argentina
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Fil: Fantilli, Anabella Clara. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
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Fil: Borda, Mariel Alejandra. Laboratorio Central de la Provincia de Cordoba; Argentina
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Fil: Canna, Fernando. Laboratorio Central de la Provincia de Cordoba; Argentina
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Fil: Barbás, Gabriela. Laboratorio Central de la Provincia de Cordoba; Argentina
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Fil: Ré, Viviana Elizabeth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Cordoba. Facultad de Medicina. Instituto de Virología; Argentina
dc.journal.title
Journal of Clinical Virology
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1386653219301337
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jcv.2019.05.014
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