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dc.contributor.author
Kamper, Peter
dc.contributor.author
Lugvigsen, Maja
dc.contributor.author
Bendix, Knud
dc.contributor.author
Hamilton Dutoit, Stephen
dc.contributor.author
Rabinovich, Gabriel Adrián
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dc.contributor.author
Boe Møller, Michael
dc.contributor.author
Nyengaard, Jens
dc.contributor.author
Honoré, Bent
dc.contributor.author
d'Amore, Franceso
dc.date.available
2017-01-02T14:51:24Z
dc.date.issued
2011-06
dc.identifier.citation
Kamper, Peter; Lugvigsen, Maja; Bendix, Knud; Hamilton Dutoit, Stephen; Rabinovich, Gabriel Adrián; et al.; Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma; American Society Of Hematology; Blood, The Journal Of The American Society Of Hematology - Print; 117; 24; 6-2011; 6638-6649
dc.identifier.issn
0006-4971
dc.identifier.uri
http://hdl.handle.net/11336/10664
dc.description.abstract
Considerable effort has been spent identifying prognostic biomarkers in classic Hodgkin lymphoma (cHL). The aim of our study was to search for possible prognostic parameters in advanced-stage cHL using a proteomics-based strategy. A total of 14 cHL pretreatment tissue samples from younger, advanced-stage patients were included. Patients were grouped according to treatment response. Proteins that were differentially expressed between the groups were analyzed using 2D-PAGE and identified by liquid chromatography mass spectrometry. Selected proteins were validated using Western blot analysis. One of the differentially expressed proteins, the carbohydrate-binding protein galectin-1 (Gal-1), was further analyzed using immunohistochemistry HC and its expression was correlated with clinicopathologic and outcome parameters in 143 advanced-stage cHL cases. At the univariate level, high Gal-1 expression in the tumor microenvironment was correlated with poor event-free survival (P = .02). Among younger (≤ 61 years) patients, high Gal-1 was correlated with poorer overall and event-free survival (both P = .007). In this patient group and at the multivariate level, high Gal-1 expression retained a significant predictive impact on event-free survival. Therefore, in addition to its functional role in cHL-induced immunosuppression, Gal-1 is also associated with an adverse clinical outcome in this disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society Of Hematology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Hodgkin Lymphoma
dc.subject
Biomarker
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Galectin-1
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Proteomics
dc.subject.classification
Patología
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Proteomic analysis identifies galectin-1 as a predictive biomarker for relapsed/refractory disease in classical Hodgkin lymphoma
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-30T13:43:20Z
dc.journal.volume
117
dc.journal.number
24
dc.journal.pagination
6638-6649
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Chicago
dc.description.fil
Fil: Kamper, Peter. Aarhus University Hospital. Department of Hematology; Dinamarca
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Fil: Lugvigsen, Maja. University Aarhus; Dinamarca
dc.description.fil
Fil: Bendix, Knud. Aarhus University Hospital. Institute of Pathology; Dinamarca
dc.description.fil
Fil: Hamilton Dutoit, Stephen. Aarhus University Hospital. Institute of Pathology; Dinamarca
dc.description.fil
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
dc.description.fil
Fil: Boe Møller, Michael. Odense University Hospital. Department of Pathology; Dinamarca
dc.description.fil
Fil: Nyengaard, Jens. Aarhus University Hospital. Center for Stochastic Geometry and Advanced
Bioimaging. Stereology & Electron Microscopy Laboratory; Dinamarca
dc.description.fil
Fil: Honoré, Bent. University Aarhus; Dinamarca
dc.description.fil
Fil: d'Amore, Franceso. Aarhus University Hospital. Department of Hematology; Dinamarca
dc.journal.title
Blood, The Journal Of The American Society Of Hematology - Print
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.bloodjournal.org/content/117/24/6638
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1182/blood-2010-12-327346
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