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dc.contributor.author
Petit, Daniel
dc.contributor.author
Teppa, Roxana Elin
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dc.contributor.author
Petit, Jean Michel
dc.contributor.author
Harduin Lepers, Anne
dc.contributor.other
Brockhausen, Inka
dc.date.available
2020-06-03T14:09:54Z
dc.date.issued
2013
dc.identifier.citation
Petit, Daniel; Teppa, Roxana Elin; Petit, Jean Michel; Harduin Lepers, Anne; A practical approach to reconstruct evolutionary history of animal sialyltransferases and gain insights into the sequence-function relationships of Golgi-glycosyltransferases; Humana Press; 1022; 2013; 73-97
dc.identifier.isbn
978-1-62703-464-7
dc.identifier.uri
http://hdl.handle.net/11336/106578
dc.description.abstract
In higher vertebrates, sialyltransferases catalyze the transfer of sialic acid residues, either Neu5Ac or Neu5Gc or KDN from an activated sugar donor, which is mainly CMP-Neu5Ac in human tissues, to the hydroxyl group of another saccharide acceptor. In the human genome, 20 unique genes have been described that encode enzymes with remarkable specificity with regards to their acceptor substrates and the glycosidic linkage formed. A systematic search of sialyltransferase-related sequences in genome and EST databases and the use of bioinformatic tools enabled us to investigate the evolutionary history of animal sialyltransferases and propose original models of divergent evolution of animal sialyltransferases. In this chapter, we extend our phylogenetic studies to the comparative analysis of the environment of sialyltransferase gene loci (synteny and paralogy studies), the variations of tissue expression of these genes and the analysis of amino-acid position evolution after gene duplications, in order to assess their sequence-function relationships and the molecular basis underlying their functional divergence.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Humana Press
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SIALYLTRANSFERASES
dc.subject
MOLECULAR PHYLOGENY
dc.subject
PHYLOGENOMICS
dc.subject
GLYCOSILATION
dc.subject.classification
Bioquímica y Biología Molecular
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
A practical approach to reconstruct evolutionary history of animal sialyltransferases and gain insights into the sequence-function relationships of Golgi-glycosyltransferases
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-04-24T19:01:58Z
dc.journal.volume
1022
dc.journal.pagination
73-97
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Petit, Daniel. Universite de Limoges; Francia
dc.description.fil
Fil: Teppa, Roxana Elin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
dc.description.fil
Fil: Petit, Jean Michel. Universite de Limoges; Francia
dc.description.fil
Fil: Harduin Lepers, Anne. Universite de Limoges; Francia
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-62703-465-4_7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-62703-465-4_7
dc.conicet.paginas
425
dc.source.titulo
Glycosyltransferases : Methods and Protocols
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