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dc.contributor.author
Torta, Diana M.
dc.contributor.author
Jure, Fabricio A.
dc.contributor.author
Andersen, Ole K.
dc.contributor.author
Biurrun Manresa, José Alberto
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dc.date.available
2020-06-03T12:31:03Z
dc.date.issued
2019-08
dc.identifier.citation
Torta, Diana M.; Jure, Fabricio A.; Andersen, Ole K.; Biurrun Manresa, José Alberto; Intense and sustained pain reduces cortical responses to auditory stimuli: Implications for the interpretation of the effects of heterotopic noxious conditioning stimulation in humans; Wiley Blackwell Publishing, Inc; European Journal Of Neuroscience; 8-2019; 1-10
dc.identifier.issn
0953-816X
dc.identifier.uri
http://hdl.handle.net/11336/106559
dc.description.abstract
Phasic pain stimuli are inhibited when they are applied concomitantly with a conditioning tonic stimulus at another body location (heterotopic noxious conditioning stimulation, HNCS). While the effects of HNCS are thought to rely on a spino-bulbo-spinal mechanism in animals (termed diffuse noxious inhibitory controls, DNIC), the underlying neurophysiology in humans may involve other pathways. In this study, we investigated the role of concomitant supraspinal mechanisms during HNCS by presenting auditory stimuli during a conditioning tonic painful stimulus (the cold pressor test, CPT). Considering that auditory stimuli are not conveyed through the spinal cord, any changes in brain responses to auditory stimuli during HNCS can be ascribed entirely to supraspinal mechanisms. Electroencephalography (EEG) was recorded during HNCS, and auditory stimuli were administered in three blocks, before, during and after HNCS. Nociceptive withdrawal reflexes (NWRs) were recorded at the same time points to investigate spinal processing. Our results showed that AEPs were significantly reduced during HNCS. Moreover, the amplitude of the NWR was significantly diminished during HNCS in most participants. Given that spinal and supraspinal mechanisms operate concomitantly during HNCS, the possibility of isolating their individual contributions in humans is questionable. We conclude that the net effects of HCNS are not independent from attentional/cognitive influences.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley Blackwell Publishing, Inc
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dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
COGNITION
dc.subject
CONDITIONED PAIN MODULATION
dc.subject
EVENT-RELATED POTENTIALS
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HETEROTOPIC NOXIOUS CONDITIONING STIMULATION
dc.subject
PAIN
dc.subject.classification
Ingeniería Médica
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dc.subject.classification
Ingeniería Médica
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dc.subject.classification
INGENIERÍAS Y TECNOLOGÍAS
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dc.title
Intense and sustained pain reduces cortical responses to auditory stimuli: Implications for the interpretation of the effects of heterotopic noxious conditioning stimulation in humans
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-06-01T13:38:57Z
dc.journal.pagination
1-10
dc.journal.pais
Reino Unido
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dc.journal.ciudad
Londres
dc.description.fil
Fil: Torta, Diana M.. Université Catholique de Louvain; Bélgica. Katholikie Universiteit Leuven; Bélgica
dc.description.fil
Fil: Jure, Fabricio A.. Aalborg Universitet;
dc.description.fil
Fil: Andersen, Ole K.. Aalborg Universitet;
dc.description.fil
Fil: Biurrun Manresa, José Alberto. Universidad Nacional de Entre Ríos. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Investigación y Desarrollo en Bioingeniería y Bioinformática; Argentina
dc.journal.title
European Journal Of Neuroscience
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/ejn.14546
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