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dc.contributor.author
Koehler, Niklas K. U.
dc.contributor.author
Stransky, Elle
dc.contributor.author
Meyer, Mirjam
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Gaertner, Susanne
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Shing, Mona
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Schnaidt, Martina
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Celej, Maria Soledad
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Jovin, Thomas M.
dc.contributor.author
Leyhe, Thomas
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Laske, Christoph
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Batra, Anil
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Buchkremer, Gerhard
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Fallgatter, Andreas J.
dc.contributor.author
Wernet, Dorothee
dc.contributor.author
Richartz Salzburger, Elke
dc.date.available
2016-12-29T21:19:30Z
dc.date.issued
2015-04
dc.identifier.citation
Koehler, Niklas K. U.; Stransky, Elle; Meyer, Mirjam; Gaertner, Susanne; Shing, Mona; et al.; Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging; Public Library of Science; Plos One; 10; 4; 4-2015; 1-16
dc.identifier.issn
1932-6203
dc.identifier.uri
http://hdl.handle.net/11336/10653
dc.description.abstract
There is unequivocal evidence that alpha-synuclein plays a pivotal pathophysiological role in neurodegenerative diseases, and in particular in synucleinopathies. These disorders present with a variable extent of cognitive impairment and alpha-synuclein is being explored as a biomarker in CSF, blood serum and plasma. Considering key events of aging that include proteostasis, alpha-synuclein may not only be useful as a marker for differential diagnosis but also for aging per se. To explore this hypothesis, we developed a highly specific ELISA to measure alpha-synuclein. In healthy males plasma alpha-synuclein levels correlated strongly with age, revealing much lower concentrations in older (avg. 58.1 years) compared to younger (avg. 27.6 years) individuals. This difference between the age groups was enhanced after acidification of the plasmas (p<0.0001), possibly reflecting a decrease of alpha-synuclein-antibody complexes or chaperone activity in older individuals. Our results support the concept that alpha-synuclein homeostasis may be impaired early on, possibly due to disturbance of the proteostasis network, a key component of healthy aging. Thus, alpha-synuclein may be a novel biomarker of aging, a factor that should be considered when analyzing its presence in biological specimens.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Alpha-Synuclein
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Parkinson
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Blood Plasma
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Biomarker
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Neurociencias
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Alpha-Synuclein Levels in Blood Plasma Decline with Healthy Aging
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-28T17:54:42Z
dc.journal.volume
10
dc.journal.number
4
dc.journal.pagination
1-16
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Koehler, Niklas K. U.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
dc.description.fil
Fil: Stransky, Elle. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Meyer, Mirjam. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Gaertner, Susanne. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Shing, Mona. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Schnaidt, Martina. Zentrum für Klinische Transfusionsmedizin; Alemania
dc.description.fil
Fil: Celej, Maria Soledad. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Quimica Biológica; Argentina. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Química Biológica de Córdoba (p); Argentina
dc.description.fil
Fil: Jovin, Thomas M.. Institute for Biophysical Chemistry. Laboratory for Cellular Dynamics, Max-Planck; Alemania
dc.description.fil
Fil: Leyhe, Thomas. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. Psychiatric University Hospital. Center of Old Age Psychiatry; Alemania
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Fil: Laske, Christoph . Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania. German Center for Neurodegenerative Diseases; Alemania
dc.description.fil
Fil: Batra, Anil. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Buchkremer, Gerhard. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Fallgatter, Andreas J.. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.description.fil
Fil: Wernet, Dorothee. Zentrum für Klinische Transfusionsmedizin; Alemania
dc.description.fil
Fil: Richartz Salzburger, Elke. Eberhard-Karls-University Tübingen. Department of Psychiatry and Psychotherapy; Alemania
dc.journal.title
Plos One
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123444
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pone.0123444


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