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dc.contributor.author
Igarza, Leticia Manuela
dc.contributor.author
Soraci, Alejandro Luis
dc.contributor.author
Auza, Nestor Julio
dc.contributor.author
Zeballos, Horacio
dc.date.available
2020-06-02T17:00:01Z
dc.date.issued
2004-01
dc.identifier.citation
Igarza, Leticia Manuela; Soraci, Alejandro Luis; Auza, Nestor Julio; Zeballos, Horacio; Some Pharmacokinetic Parameters of R-(–)- and S-(+)-Ketoprofen: The Influence of Age and Differing Physiological Status in Dairy Cattle; Springer; Veterinary Research Communications; 28; 1; 1-2004; 81-87
dc.identifier.issn
0165-7380
dc.identifier.uri
http://hdl.handle.net/11336/106488
dc.description.abstract
The pharmacokinetic parameters of ketoprofen have previously been studied in cattle, but no studies have been performed on differing ages and metabolic situations in these animals. The aim of this work was to study the possible modifictions of the pharmacokinetics of ketoprofen enantiomers that may result from age, lactation or gestation in dairy cattle. Three groups of Holando Argentino cattle contained, respectively, 8 cows in early lactation, 8 pregnant cows and 8 newborn calves. Four animals from each group received the enantiomer R-(–)-ketoprofen, the other four animals received the S-(+) enantiomer, all by intravenous injection at a dose of 0.5 mg/kg. Significant differences between the three categories of animals were obtained in elimination half-life (t 1/2) (1.52, 0.87 and 0.31 and 1.71, 0.69 and 0.26 in newborn calves, cows in early lactation and cows in gestation, respectively), mean residence time (MRT) (0.45, 1.25, 2.20 and 0.38, 0.99, 2.47 h, in cows in gestation, cows in early lactation and newborn calves, respectively) and area under the plasma concentration-time curve (AUC) (0.87, 2.93, 3.24, and 0.67, 2.78, 5.13 (g/h)/ml in cows in gestation, cows in early lactation and newborn calves, respectively, for the R-(–) and S-(+) enantiomer, respectively. In calves, there was a significant difference in AUC (3.24 vs 5.13 (g h)/ml between R-(–)- and S-(+)-ketoprofen. In view of the differences between calves and adult cattle in the pharmacokinetic results for ketoprofen, the effects of age and physiological status (lactation, gestation) should be taken into account for therapeutic regimens.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
AGE
dc.subject
CATTLE
dc.subject
ENANTIOMERS
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GESTATION
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KETOPROFEN
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LACTATION
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PHARMACOKINETICS
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PRE-RUMINANTS
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Toxicología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Some Pharmacokinetic Parameters of R-(–)- and S-(+)-Ketoprofen: The Influence of Age and Differing Physiological Status in Dairy Cattle
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-27T17:10:58Z
dc.identifier.eissn
1573-7446
dc.journal.volume
28
dc.journal.number
1
dc.journal.pagination
81-87
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Igarza, Leticia Manuela. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
dc.description.fil
Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Auza, Nestor Julio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
dc.description.fil
Fil: Zeballos, Horacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina
dc.journal.title
Veterinary Research Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1023/b:verc.0000009534.64533.b9
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/B:VERC.0000009534.64533.b9
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