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dc.contributor.author
Montoya, Laura
dc.contributor.author
Ambros, Luis
dc.contributor.author
Kreil, Verónica Elizabeth
dc.contributor.author
Bonafine, Ricardo
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Albarellos, Gabriela Alejandra
dc.contributor.author
Hallu, Ruben Eduardo
dc.contributor.author
Soraci, Alejandro Luis
dc.date.available
2020-06-02T16:51:31Z
dc.date.issued
2004-07
dc.identifier.citation
Montoya, Laura; Ambros, Luis; Kreil, Verónica Elizabeth; Bonafine, Ricardo; Albarellos, Gabriela Alejandra; et al.; A Pharmacokinetic Comparison of Meloxicam and Ketoprofen following Oral Administration to Healthy Dogs; Springer; Veterinary Research Communications; 28; 5; 7-2004; 415-428
dc.identifier.issn
0165-7380
dc.identifier.uri
http://hdl.handle.net/11336/106487
dc.description.abstract
Ketoprofen (KTP) and meloxicam (MLX) are non-steroidal anti-inflamatory drugs used extensively in veterinary medicine. The pharmacokinetics of these drugs were studied in eight dogs following a single oral dose of 1 mg/kg of KTP as a racemate or 0.2 mg/kg of MLX. The concentrations of the drugs in plasma were determined by high-performance liquid chromatography (HPLC). There were differences between the disposition curves of the KTP enantiomers, confirming that the pharmacokinetics of KTP is enantioselective. (S)-(+)-KTP was the predominant enantiomer; the S:R ratio in the plasma increased from 2.58±0.38 at 15 min to 5.72±2.35 at 1 h. The area under the concentration–time curve (AUC) of (S)-(+)-KTP was approximately 6 times greater than that of (R)-(–)-KTP. The mean (±SD) pharmacokinetic parameters for (S)-(+)-KTP were characterized as T max = 0.76±0.19 h, C max = 2.02±0.41 μg/ml, t t12el = 1.65±0.48 h, AUC = 6.06±1.16 μg.h/ml, V d/F = 0.39±0.07 L/kg, Cl/F = 170±39 ml/(kg.h). The mean (±SD) pharmacokinetic parameters of MLX were T max = 8.5±1.91 h, C max = 0.82±0.29 μg/ml, t t12λ(z) = 12.13±2.15 h, AUCinf = 15.41±1.24 μg.h/ml, V d/F = 0.23±0.03 L/kg, and Cl/F = 10±1.4 ml/(kg.h). Our results indicate significant pharmacokinetic differences between MLX and KTP after therapeutic doses.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
DOGS
dc.subject
KETOPROFEN
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MELOXICAM
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NSAID
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PHARMACOKINETICS
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Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
A Pharmacokinetic Comparison of Meloxicam and Ketoprofen following Oral Administration to Healthy Dogs
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-27T17:10:29Z
dc.identifier.eissn
1573-7446
dc.journal.volume
28
dc.journal.number
5
dc.journal.pagination
415-428
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Montoya, Laura. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.description.fil
Fil: Ambros, Luis. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.description.fil
Fil: Kreil, Verónica Elizabeth. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.description.fil
Fil: Bonafine, Ricardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.description.fil
Fil: Albarellos, Gabriela Alejandra. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.description.fil
Fil: Hallu, Ruben Eduardo. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias. Área de Farmacología; Argentina
dc.description.fil
Fil: Soraci, Alejandro Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.journal.title
Veterinary Research Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1023/b:verc.0000034995.81994.49
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/10.1023/B:VERC.0000034995.81994.49
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