Biomolecular interfaces: interactions, functions and drug design

Abstract

The book deals with a largely overlooked area of molecular biophysics that is likely to have strong impact on molecularly targeted medicine and drug design: the aqueous interface of a soluble protein. Foundational knowledge is presented in the first seven chapters and enables the reader to effectively tackle major problems in biophysics, such as the protein folding problem and the therapeutic disruption of protein–protein associations. These advances have been heralded by others, as is evident, for example, in a recent review published in Scientific American by Philip Ball.