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dc.contributor.author
Leal, Maria Celeste  
dc.contributor.author
Morelli, Laura  
dc.contributor.other
Rawlings, Neil D.  
dc.contributor.other
Salvesen, Guy  
dc.date.available
2020-05-27T21:13:45Z  
dc.date.issued
2013  
dc.identifier.citation
Leal, Maria Celeste; Morelli, Laura; Insulysin; Elsevier; 2013; 1415-1420  
dc.identifier.isbn
978-0-12-382219-2  
dc.identifier.uri
http://hdl.handle.net/11336/106072  
dc.description.abstract
Insulysin appears to be responsible for the majority of the insulin-degrading activity in most cell lysates. It is inhibited by both chelating agents and alkylating agents. Because of its high affinity for insulin, it is possible to test whether a particular substrate may be cleaved by this enzyme by determining whether insulin inhibits its degradation. Both polyclonal antisera and a monoclonal antibody against the enzyme have been described and are commercially available. Finally, a fluorogenic synthetic substrate, 2-aminobenzyl-GGFLRKVGQ-ethylenediamine-2,4-dinitrophenol, has been described for assaying insulysin and inhibitors for IDE activity were recently reported.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
PROTEASA  
dc.subject
INSULINASA  
dc.subject
METALOPEPTIDASA  
dc.subject
M16  
dc.subject.classification
Bioquímica y Biología Molecular  
dc.subject.classification
Ciencias Biológicas  
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS  
dc.title
Insulysin  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.type
info:eu-repo/semantics/bookPart  
dc.type
info:ar-repo/semantics/parte de libro  
dc.date.updated
2020-04-24T19:02:05Z  
dc.journal.pagination
1415-1420  
dc.journal.pais
Países Bajos  
dc.description.fil
Fil: Leal, Maria Celeste. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.description.fil
Fil: Morelli, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/B9780123822192003197  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/B978-0-12-382219-2.00319-7  
dc.conicet.paginas
4094  
dc.source.titulo
Handbook of Proteolytic Enzymes  

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