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dc.contributor.author
Bustos, Diego Martin  
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Bailey, Michael J.  
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Sugden, David  
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Carter, David  
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Rath, Martin F.  
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Møller, Morten  
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Coon, Steven L.  
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Weller, Joan L.  
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Klein, David C.  
dc.date.available
2020-05-27T19:33:37Z  
dc.date.issued
2011-02-08  
dc.identifier.citation
Bustos, Diego Martin; Bailey, Michael J.; Sugden, David; Carter, David; Rath, Martin F.; et al.; Global daily dynamics of the pineal transcriptome; Springer; Cell and Tissue Research; 344; 1; 8-2-2011; 1-11  
dc.identifier.issn
0302-766X  
dc.identifier.uri
http://hdl.handle.net/11336/106050  
dc.description.abstract
Transcriptome profiling of the pineal gland has revealed night/day differences in the expression of a major fraction of the genes active in this tissue, with two-thirds of these being nocturnal increases. A set of over 600 transcripts exhibit two-fold to >100-fold daily differences in abundance. These changes appear to be primarily attributable to adrenergic-cyclic-AMP-dependent mechanisms, which are controlled via a neural pathway that includes the suprachiasmatic nucleus, the master circadian oscillator. In addition to melatonin synthesis, night/day differences in gene expression impact genes associated with several specialized functions, including the immune/inflammation response, photo-transduction, and thyroid hormone/retinoic acid biology. The following nonspecialized cellular features are also affected: adhesion, cell cycle/cell death, cytoskeleton, DNA modification, endothelium, growth, RNA modification, small molecule biology, transcription factors, vesicle biology, signaling involving Ca2+, cyclic nucleotides, phospholipids, mitogen-activated protein kinases, the Wnt signaling pathway, and protein phosphorylation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
SEQUENCIACION MASIVA  
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TRANSCRIPTOMA  
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BIOINFORMATICA  
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GLANDULA PINEAL  
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Biología  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Global daily dynamics of the pineal transcriptome  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-05-04T19:55:26Z  
dc.journal.volume
344  
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1  
dc.journal.pagination
1-11  
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Alemania  
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Berlín  
dc.description.fil
Fil: Bustos, Diego Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina  
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Fil: Bailey, Michael J.. Texas A&M University; Estados Unidos  
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Fil: Sugden, David. King’s College London. School of Biomedical and Health Sciences. Division of Reproduction and Endocrinology; Reino Unido  
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Fil: Carter, David. Cardiff University; Reino Unido  
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Fil: Rath, Martin F.. Universidad de Copenhagen; Dinamarca  
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Fil: Møller, Morten. Universidad de Copenhagen; Dinamarca  
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Fil: Coon, Steven L.. National Institutes of Health; Estados Unidos  
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Fil: Weller, Joan L.. National Institutes of Health; Estados Unidos  
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Fil: Klein, David C.. National Institutes of Health; Estados Unidos  
dc.journal.title
Cell and Tissue Research  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs00441-010-1094-1  
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info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s00441-010-1094-1