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dc.contributor.author
Sanchez Bruni, Sergio Fabian  
dc.contributor.author
Jones, Douglas G.  
dc.contributor.author
Small, John  
dc.contributor.author
McKellar, Quintin A.  
dc.date.available
2020-05-27T15:08:31Z  
dc.date.issued
2005-10  
dc.identifier.citation
Sanchez Bruni, Sergio Fabian; Jones, Douglas G.; Small, John; McKellar, Quintin A.; Effects of formulation concentration on intravenous pharmacokinetics, chirality and in vitro solubility of oxfendazole and its metabolites in sheep; Wiley Blackwell Publishing, Inc; Journal of Veterinary Pharmacology and Therapeutics; 28; 5; 10-2005; 467-473  
dc.identifier.issn
0140-7783  
dc.identifier.uri
http://hdl.handle.net/11336/106015  
dc.description.abstract
This study compared pharmacokinetic (PK) profiles in sheep dosed intravenously with three different concentrations of oxfendazole (OFZ).  An in vitro plasma OFZ dissolution study provided additional information on plasma saturation.  For the PK study, 18 adult, parasite-free, female Suffolk cross sheep, allocated into three groups (n=6), were treated intravenously, at a dose rate of 5mg/kg bodyweight, with aqueous solutions containing at 4, 8 or 16% OFZ.  Plasma drug concentrations were measured, for up to 72 hours post-treatment, by a validated high performance liquid chromatography (HPLC) method with UV detection.  OFZ and fenbendazole sulphone (FBZSO2) were the main metabolites detected in all three experimental groups. In animals given the 4% solution, OFZ depleted according to a biexponential concentration vs. time curve.  In contrast, those given 8 or 16% preparations produced atypical curves fitted by monoexponential equations. No statistically significant differences in area under concentration-time curves (AUC) were observed, but concentration-dependent differences in distribution and mean residence time (MRT) were evident.  Compared with 4% OFZ, animals treated with 8 and 16% formulations had slower half-lives of metabolite formation,and lower AUC’s, suggesting that OFZ sulphonation may have been modified.  In vitro there was evidence of plasma saturation and precipitation associated with 8 and 16% OFZ preparations.  It is concluded that differences in PK profiles, in vivo, may have been related to inadequate dissolution and/or tissue drug precipitation.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Wiley Blackwell Publishing, Inc  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
PHARMACOKINETICS  
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BENZIMIDAZOLES  
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CHILARITY  
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SHEEP  
dc.subject.classification
Ciencias Veterinarias  
dc.subject.classification
Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Effects of formulation concentration on intravenous pharmacokinetics, chirality and in vitro solubility of oxfendazole and its metabolites in sheep  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-05-19T17:25:39Z  
dc.identifier.eissn
1365-2885  
dc.journal.volume
28  
dc.journal.number
5  
dc.journal.pagination
467-473  
dc.journal.pais
Reino Unido  
dc.journal.ciudad
Londres  
dc.description.fil
Fil: Sanchez Bruni, Sergio Fabian. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Jones, Douglas G.. Moredun Research Institute. Pentlands Science Park; Reino Unido  
dc.description.fil
Fil: Small, John. Moredun Research Institute. Pentlands Science Park; Reino Unido  
dc.description.fil
Fil: McKellar, Quintin A.. Moredun Research Institute. Pentlands Science Park; Reino Unido  
dc.journal.title
Journal of Veterinary Pharmacology and Therapeutics  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1111/j.1365-2885.2005.00678.x  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1365-2885.2005.00678.x