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dc.contributor.author
Imperiale, Fernanda Andrea
dc.contributor.author
Pis, Alejandra
dc.contributor.author
Sallovitz, Juan Manuel
dc.contributor.author
Lifschitz, Adrian Luis
dc.contributor.author
Busetti, Margarita Rosa
dc.contributor.author
Suarez, Víctor Humberto
dc.contributor.author
Lanusse, Carlos Edmundo
dc.date.available
2020-05-27T13:44:49Z
dc.date.issued
2006-10
dc.identifier.citation
Imperiale, Fernanda Andrea; Pis, Alejandra; Sallovitz, Juan Manuel; Lifschitz, Adrian Luis; Busetti, Margarita Rosa; et al.; Pattern of Eprinomectin Milk Excretion in Dairy Sheep Unaffected by Lactation Stage: Comparative Residual Profiles in Dairy Products; International Association for Food Protection; Journal of Food Protection; 69; 10; 10-2006; 2424-2429
dc.identifier.issn
0362-028X
dc.identifier.uri
http://hdl.handle.net/11336/105978
dc.description.abstract
Eprinomectin (EPM) is a broad-spectrum endectocide compound approved for use in dairy cattle with a zero milk-withdrawal period, but has not been registered for use in lactating dairy sheep. The pattern of EPM excretion in milk was comparatively characterized following its pour-on administration (500 microg/kg) to lactating dairy sheep at two different stages of lactation. The relationship between milk excretion and plasma disposition kinetics of EPM was characterized. Residual EPM concentrations were assessed during cheese making (whey and curd) and ripening (cheese) by high-performance liquid chromatography and fluorescence detection. EPM was poorly distributed from the bloodstream to the mammary gland and low concentrations were excreted in milk. The level of milk production (early-mid and mid-late lactation) did not affect either the plasma-milk distribution or the pattern of residual concentrations in milk. During cheese making, the highest residual concentrations of EPM were measured in the curd, which increased during cheese ripening, reaching a maximum after 40 days. However, these residual concentrations were below the maximum residue limit of 20 ng/ml established for EPM in bovine´s milk. Therefore, these dairy products could be considered safe for consumers after the EPM antiparasitic pour-on treatment (500 microg/kg) in lactating dairy sheep.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
International Association for Food Protection
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EPRINOMECTIN
dc.subject
DAIRY CATTLE
dc.subject.classification
Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Pattern of Eprinomectin Milk Excretion in Dairy Sheep Unaffected by Lactation Stage: Comparative Residual Profiles in Dairy Products
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-05T16:08:17Z
dc.identifier.eissn
1944-9097
dc.journal.volume
69
dc.journal.number
10
dc.journal.pagination
2424-2429
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Des Moines
dc.description.fil
Fil: Imperiale, Fernanda Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Pis, Alejandra. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Sallovitz, Juan Manuel. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina
dc.description.fil
Fil: Lifschitz, Adrian Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Busetti, Margarita Rosa. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina
dc.description.fil
Fil: Suarez, Víctor Humberto. Instituto Nacional de Tecnología Agropecuaria. Centro Regional La Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina
dc.description.fil
Fil: Lanusse, Carlos Edmundo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.journal.title
Journal of Food Protection
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.4315/0362-028x-69.10.2424
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://meridian.allenpress.com/jfp/article/69/10/2424/171934/Pattern-of-Eprinomectin-Milk-Excretion-in-Dairy
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