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dc.contributor.author
Sookoian, Silvia Cristina
dc.contributor.author
Gemma, Carolina
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Fernández Gianotti, Tomás
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Burgueño, Adriana Laura
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Alvarez, Azucena
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González, Claudio Daniel
dc.contributor.author
Pirola, Carlos José
dc.date.available
2020-05-26T20:45:37Z
dc.date.issued
2007-08
dc.identifier.citation
Sookoian, Silvia Cristina; Gemma, Carolina; Fernández Gianotti, Tomás; Burgueño, Adriana Laura; Alvarez, Azucena; et al.; Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers; Oxford University Press; Sleep.; 30; 8; 8-2007; 1049-1053
dc.identifier.issn
0161-8105
dc.identifier.uri
http://hdl.handle.net/11336/105947
dc.description.abstract
Study Objectives: Because serotonin is a neurotransmitter associated with circadian rhythm regulation, we explored a possible relationship of serotonin (5-HT), serotonin metabolite, 5-hydroxyindolacetic acid (5-HIAA), and the functional polymorphism of the serotonin transporter gene (SLC6A4) promoter with rotating shift work. Design & Participants: 683 men were included in this study: 437 day-workers were compared with 246 rotating shift-workers. Results: Platelet 5-HT content differed significantly (p=0.002) between day-workers (41.28±1.99 pg/mg) and rotating shift-workers (37.91±4.16 pg/mg). Accordingly, 5-HIAA content was also significantly (p=0.00004) higher in day-workers (11.40±0.82 pg/mg) in comparison with rotating shift-workers (9.33±1.02 pg/mg). We looked for further differences in SLC6A4 promoter (5-HTTLPR, 44 bp insertion: long (L)/deletion: short (S) alleles). We found a significant (p< 0.008) difference in genotypes distribution between day-workers (LL: 126, LS: 202, and SS: 109 individuals) and rotating shift-workers (LL: 47, LS: 124 and SS: 75 individuals). Logistic regression analysis showed that rotating shift work was associated with S allele independently of work time exposure (Estimate±SE: 0.27±0.11, p<0.015). Besides, there was a significantly lower content of platelet 5-HIAA in S allele carriers in comparison with the other genotypes (SS: 9.2±1.0 pg/mg vs. SL/LL: 11.0±0.8 pg/mg, p<0.02). In conclusion, platelet 5-HT and 5-HIAA contents were significantly lower in rotating shift-workers in comparison with day-workers and there was a significant association between the S variant of SLC6A4 promoter and shift work. These findings may be important for targeting effective therapeutic strategies to ameliorate the associated co- morbidities and behavioral problems in rotating shift workers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Oxford University Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ROTATING SHIFT WORK
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SEROTONIN
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5-HIAA
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SLC6A4
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GENTICS
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Biología Celular, Microbiología
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Ciencias Biológicas
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CIENCIAS NATURALES Y EXACTAS
dc.title
Serotonin and Serotonin Transporter Gene Variant in Rotating Shift Workers
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-11T18:19:55Z
dc.journal.volume
30
dc.journal.number
8
dc.journal.pagination
1049-1053
dc.journal.pais
Reino Unido
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Gemma, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Fernández Gianotti, Tomás. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Burgueño, Adriana Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: Alvarez, Azucena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.description.fil
Fil: González, Claudio Daniel. Universidad de Buenos Aires. Facultad de Medicina; Argentina
dc.description.fil
Fil: Pirola, Carlos José. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina
dc.journal.title
Sleep.
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/sleep/article/30/8/1049/2696794
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1093/sleep/30.8.1049
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