Artículo

RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis

Colo, Georgina PamelaIcon ; Rosato, Roberto R.; Grant, Steven; Costas, Monica AlejandraIcon
Fecha de publicación: 10/2007
Editorial: Elsevier Science
Revista: FEBS Letters
ISSN: 0014-5793
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

The nuclear receptor coactivator RAC3 plays important roles in many biological processes and tumorigenesis. We found that RAC3 is over-expressed in human chronic myeloid leukemia cells K562, which are normally resistant to TRAIL-induced apoptosis. RAC3 down-regulation by siRNA rendered these cells sensitive to TRAIL-induced cell death. In addition to the up-regulation of TRAIL receptors, the process involves Bid, caspases and PARP activation, loss of mitochondrial membrane potential, and release of AIF, cytochrome c and Smac/DIABLO to the cytoplasm. We conclude that RAC3 is required for TRAIL resistance and that this anti-apoptotic function is independent of its role in hormone receptor signaling.
Palabras clave: Nuclear receptors coactivator , RAC3 , Apoptosis , Leukemia , TRAIL , NF-kappaB
 
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/105931
URL: https://febs.onlinelibrary.wiley.com/doi/full/10.1016/j.febslet.2007.09.052
DOI: https://doi.org/10.1016/j.febslet.2007.09.052
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Citación
Colo, Georgina Pamela; Rosato, Roberto R.; Grant, Steven; Costas, Monica Alejandra; RAC3 down-regulation sensitizes human chronic myeloid leukemia cells to TRAIL-induced apoptosis; Elsevier Science; FEBS Letters; 581; 26; 10-2007; 5075-5081
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