Artículo
Self-fluorescent antibiotic MoOx–hydroxyapatite: a nano-theranostic platform for bone infection therapies
Placente, Damián
; Ruso, Juan Manuel; Baldini, Monica Diana; Laiuppa, Juan Andrés
; Sieben, Juan Manuel
; Santillán, Graciela Edith
; Messina, Paula Verónica
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Fecha de publicación:
07/08/2019
Editorial:
Royal Society of Chemistry
Revista:
Nanoscale
ISSN:
2040-3372
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
Nowadays, the repair of large-size bone defects represents a huge medical challenge. A line of attack is the construction of advanced biomaterials having multifunctional properties. In this work, we show the creation of biocompatible MoOx-hydroxyapatite nanoparticles (nano-HA/MoOx) that simultaneously exhibit self-activated fluorescence and antibiotic skills. Along this text, we demonstrate that the insertion of molybdenum, an essential trace element, into the non-stoichiometric calcium deficient hydroxyapatite lattice generates intrinsic electronic point defects that exacerbate its epifluorescence blue emission and provokes new red emissions, preserving, always, its bioactivity. Furthermore, these point defects, acting as electron acceptors, stimulate the materials´ biological redox status and promote the death of pathogen microorganisms after their direct contact. A putative mechanism, by which bacteria lose electrons from their metabolic circuit that alter the function of their cytoplasmic membrane and potentially die, agrees with our results. Our findings highlight the importance of tuning the electronic communications between biomaterial interfaces and biological units, and support the use of self-fluorescent MoOx-hydroxyapatite nanoparticles as fundamental building blocks for new real-time imaging platforms against bone infection.
Palabras clave:
SELF-FLUORESCENT
,
ANTIBIOTIC
,
MOOX-HYDROXYAPATITE
,
BONE
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Identificadores
Colecciones
Articulos(INBIOSUR)
Articulos de INSTITUTO DE CIENCIAS BIOLOGICAS Y BIOMEDICAS DEL SUR
Articulos de INSTITUTO DE CIENCIAS BIOLOGICAS Y BIOMEDICAS DEL SUR
Articulos(INQUISUR)
Articulos de INST.DE QUIMICA DEL SUR
Articulos de INST.DE QUIMICA DEL SUR
Citación
Placente, Damián; Ruso, Juan Manuel; Baldini, Monica Diana; Laiuppa, Juan Andrés; Sieben, Juan Manuel; et al.; Self-fluorescent antibiotic MoOx–hydroxyapatite: a nano-theranostic platform for bone infection therapies; Royal Society of Chemistry; Nanoscale; 11; 7-8-2019; 17277-17292
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