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dc.contributor.author
Nicolás Párraga, Sara
dc.contributor.author
Gandini, Carolina Lia
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dc.contributor.author
Pimenoff, Ville N.
dc.contributor.author
Alemany, Laia
dc.contributor.author
de Sanjosé, Silvia
dc.contributor.author
Bosch, F. Xavier
dc.contributor.author
Bravo, Ignacio G.
dc.date.available
2020-05-20T15:15:38Z
dc.date.issued
2016-10
dc.identifier.citation
Nicolás Párraga, Sara; Gandini, Carolina Lia; Pimenoff, Ville N.; Alemany, Laia; de Sanjosé, Silvia; et al.; HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus; Wiley; Cancer Medicine; 5; 10; 10-2016; 2909-2919
dc.identifier.issn
2045-7634
dc.identifier.uri
http://hdl.handle.net/11336/105552
dc.description.abstract
Human papillomavirus (HPV)16 is the most oncogenic human papillomavirus, responsible for most papillomavirus-inducedanogenital cancers. We have explored by sequencing and phylogenetic analysis the viral variant lineages presentin 692 HPV16-monoinfected invasive anogenital cancers from Europe, Asia,and Central/South America. We have assessed the contribution of geography and anatomy to the differential prevalence of HPV16 variants and to the nonsynonymous E6 T350G polymorphism. Most (68%) of the variance in the distributionof HPV16 variants was accounted for by the differential abundance of the different viral lineages. The most prevalent variant (above 70% prevalence) in all regions and in all locations was HPV16_A1-3,except in Asia, whereHPV16_A4 predominated in anal cancers. The differential prevalence of variants as a function of geographical origin explained 9% of the variance, and the differential prevalence of variants as a function of anatomical location accountedfor less than 3% of the variance. Despite containing similar repertoires of HPV16 variants, we confirm the worldwide trend of cervical cancers being diagnosed significantly earlier than other anogenital cancers (early fifties vs. early sixties).Frequencies for alleles in the HPV16 E6 T350G polymorphism were similar across anogenital cancers from the same geographical origin. Interestingly, anogenita lcancers from Central/South America displayed higher 350G allele frequencies also within HPV16_A1-3 lineage compared with Europe. Our results demonstrate ample variation in HPV16 variants prevalence in anogenital cancers, which is partly explained by the geographical origin of the sample and only marginally explained by the anatomical location of the lesion, suggesting that tissue specialization is not essential evolutionary forces shaping HPV16 diversity in anogenital cancers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Wiley
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANOGENITAL CANCERS
dc.subject
PAPILLOMAVIRUS INFECTION AND CANCER
dc.subject
VIRAL DIVERSITY
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VIRAL EVOLUTION
dc.subject.classification
Virología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
HPV16 variants distribution in invasive cancers of the cervix, vulva, vagina, penis, and anus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-28T14:35:04Z
dc.journal.volume
5
dc.journal.number
10
dc.journal.pagination
2909-2919
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Hoboken
dc.description.fil
Fil: Nicolás Párraga, Sara. Instituto Catalán de Oncología; España
dc.description.fil
Fil: Gandini, Carolina Lia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Biología Agrícola de Mendoza. Universidad Nacional de Cuyo. Facultad de Ciencias Agrarias. Instituto de Biología Agrícola de Mendoza; Argentina. Instituto Catalán de Oncología; España
dc.description.fil
Fil: Pimenoff, Ville N.. Instituto Catalán de Oncología; España
dc.description.fil
Fil: Alemany, Laia. Instituto Catalán de Oncología; España
dc.description.fil
Fil: de Sanjosé, Silvia. Instituto Catalán de Oncología; España
dc.description.fil
Fil: Bosch, F. Xavier. Instituto Catalán de Oncología; España
dc.description.fil
Fil: Bravo, Ignacio G.. Centre National de la Recherche Scientifique. Institut de Recherche Pour Le Developpement. Departement Societes Et Sante. Laboratorio de Genetique Et Evolution Des Maladies Infectieuses; Francia
dc.journal.title
Cancer Medicine
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/cam4.870/full
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1002/cam4.870
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