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dc.contributor.author
Navarro, Lucila
dc.contributor.author
Minari, Roque Javier
dc.contributor.author
Vaillard, Santiago Eduardo
dc.date.available
2020-05-19T21:22:16Z
dc.date.issued
2019-01
dc.identifier.citation
Navarro, Lucila; Minari, Roque Javier; Vaillard, Santiago Eduardo; Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems; Royal Society of Chemistry; RSC Advances; 9; 1; 1-2019; 482-490
dc.identifier.issn
2046-2069
dc.identifier.uri
http://hdl.handle.net/11336/105513
dc.description.abstract
Elastomeric poly-ester materials have extraordinary potential for soft tissue engineering applications. In connection, in the last 10 years, cross-linkable oligo-(polyethylene glycol fumarate)s emerged as promising materials for obtaining hydrogels for bone tissue engineering applications. In this work weprepared a new family of photo-curable poly-(ethylene glycol)?fumarate elastomers with controlled structural composition. These novel elastomers were obtained by photo-curing of fumarate prepolymers based on diethylene glycol and oligo-ethylene glycols (PEGs 200 and 400), under extremely mild experimental conditions using a low power UV source. The synthesis of fumarate pre-polymers, which were obtained by thermal poly-condensation, and the photo-curing process, were both here discussed on the basis of their structural differences and proposed operating mechanisms. Finally, the photo-radical cross-linking reactions were performed in the presence of anti-cancer drugs (doxorubicin and paclitaxel), in order to evaluate the potential application of the elastomers as new eluting systems.Thus, different release profiles were obtained for hydrophilic (doxorubicin) and hydrophobic (paclitaxel) anticancer drugs, and these differences are discussed on the basis of the structure of the elastomers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Royal Society of Chemistry
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ELASTOMER
dc.subject
CONTROLLED RELEASE
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PEG-FUMARATE
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PHOTOPOLYMER
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Ingeniería de los Materiales
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Ingeniería de los Materiales
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Photo-curable poly-(ethylene glycol) fumarate elastomers with controlled structural composition and their evaluation as eluting systems
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-19T19:46:42Z
dc.journal.volume
9
dc.journal.number
1
dc.journal.pagination
482-490
dc.journal.pais
Reino Unido
dc.description.fil
Fil: Navarro, Lucila. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Minari, Roque Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.description.fil
Fil: Vaillard, Santiago Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentina
dc.journal.title
RSC Advances
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://xlink.rsc.org/?DOI=C8RA09336A
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1039/c8ra09336a
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