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dc.contributor.author
Igarza, Leticia Manuela  
dc.contributor.author
Soraci, Alejandro Luis  
dc.contributor.author
Auza, Nestor Julio  
dc.contributor.author
Zeballos, Horacio  
dc.date.available
2020-05-15T21:10:25Z  
dc.date.issued
2006-07  
dc.identifier.citation
Igarza, Leticia Manuela; Soraci, Alejandro Luis; Auza, Nestor Julio; Zeballos, Horacio; Pharmacokinetic Parameters of (R)-(−) and (S)-(+)-Flurbiprofen in Dairy Bovines; Springer; Veterinary Research Communications; 30; 5; 7-2006; 513-522  
dc.identifier.issn
0165-7380  
dc.identifier.uri
http://hdl.handle.net/11336/105300  
dc.description.abstract
The aim of the study was to evaluate the pharmacokinetics of flurbiprofen (FBP) in different age groups and physiological status groups in dairy cattle. Ten Argentine Holstein bovines were divided into three different groups: 3 cows in early lactation, 3 cows in gestation and 4 newborn calves. Based on previous experience, all the animals received racemic FBP (50:50) at a dose of 0.5 mg/kg by intravenous administration. Blood simples were taken at predetermined times after administration of flurbiprofen. Plasma enantiomer concentrations were measured by HPLC. Total body clearance (ClB) of (S)-(+)-FBP was higher in calves than in cows (114.5, 136.4, 121.4, 128.9 ìg/ml vs 22.0, 24.2, 46.5 ìg/ml and 27.6, 25.3, 34.6 ìg/ml). In calves the disposition kinetics showed stereoselective behaviour. Area under the concentration–time curve (AUC) was higher and ClB and steady-state volume of distribution (Vss) were lower for (R)-(−)-FBP than for (S)-(+)-FBP. In cows, stereoselectivity was observed in ClB and elimination half-life ( t12 ) only in the early lactation group. In this study, enantioselective metabolic behaviour of FBP under the physiological situations studied was found. Hence, it is possible that both enantiomers of flurbiprofen may contribute to the drug’s therapeutic effects, but further studies with the administration of separate enantiomers will be required to elucidate their metabolism.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Springer  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
CATTLE  
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ENANTIOMER  
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FLURBIPROFEN  
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PHARMACOKINETICS  
dc.subject.classification
Ciencias Veterinarias  
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Ciencias Veterinarias  
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CIENCIAS AGRÍCOLAS  
dc.title
Pharmacokinetic Parameters of (R)-(−) and (S)-(+)-Flurbiprofen in Dairy Bovines  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-05-05T16:05:05Z  
dc.identifier.eissn
1573-7446  
dc.journal.volume
30  
dc.journal.number
5  
dc.journal.pagination
513-522  
dc.journal.pais
Alemania  
dc.journal.ciudad
Berlín  
dc.description.fil
Fil: Igarza, Leticia Manuela. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina  
dc.description.fil
Fil: Soraci, Alejandro Luis. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Auza, Nestor Julio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina  
dc.description.fil
Fil: Zeballos, Horacio. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología; Argentina  
dc.journal.title
Veterinary Research Communications  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11259-006-3241-4  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s11259-006-3241-4