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dc.contributor.author
Lynes, John
dc.contributor.author
Koschmann, Carl
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Wibowo, Mia
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Saxena, Vandana
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Candolfi, Marianela
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Moreno Ayala, Mariela Alejandra
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Castro, Maria Graciela
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Lowenstein, Pedro R.
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Bo, Xuenong
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Verhaagen, Joost
dc.date.available
2020-05-15T20:10:46Z
dc.date.issued
2015
dc.identifier.citation
Lynes, John; Koschmann, Carl; Wibowo, Mia; Saxena, Vandana; Candolfi, Marianela; et al.; Gene Therapy Approaches using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models; Springer New York; 98; 2015; 341-354
dc.identifier.isbn
978-1-4939-2305-2
dc.identifier.uri
http://hdl.handle.net/11336/105281
dc.description.abstract
Animal models have proven invaluable for progress toward greater understanding of the etiology, pathogenesis, and genetics of a wide range of human diseases. The development of relevant brain tumor animal models is a critical resource for building our understanding of cancers that arise within the brain and for the development of novel therapies. The central role of these models is particularly apparent for gliomas, which are common and devastating primary brain tumors. Effective models accurately demonstrate pathological features and behavior that are analogous to the human disease. Models aim to develop tumors with high penetrance and low latency, features that are ideal for preclinical therapeutic development. Lentiviral vector-induced models fulfill these requirements while giving investigators excellent control over the genetic profile of resulting tumors. This flexibility is especially relevant in the context of recent advances in the understanding of the genetic lesions found in human grade IV glioma, glioblastoma multiforme (GBM). Further, these endogenous tumor models would be ideal for the testing of novel gene therapy strategies which could potentially be implemented in Phase 1 clinical trials for these devastating human brain cancers.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer New York
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ANIMAL MODEL
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LENTIVIRUS
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GLIOMA
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GENE THERAPY
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Biotecnología relacionada con la Salud
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Biotecnología de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Gene Therapy Approaches using Reproducible and Fully Penetrant Lentivirus-Mediated Endogenous Glioma Models
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/bookPart
dc.type
info:ar-repo/semantics/parte de libro
dc.date.updated
2020-04-24T13:49:34Z
dc.journal.volume
98
dc.journal.pagination
341-354
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Nueva York
dc.description.fil
Fil: Lynes, John. University Of Michigan Medical School; Estados Unidos
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Fil: Koschmann, Carl. University Of Michigan Medical School; Estados Unidos
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Fil: Wibowo, Mia. University Of Michigan Medical School; Estados Unidos
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Fil: Saxena, Vandana. University Of Michigan Medical School; Estados Unidos
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Fil: Candolfi, Marianela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
dc.description.fil
Fil: Moreno Ayala, Mariela Alejandra. University Of Michigan Medical School; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas; Argentina
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Fil: Castro, Maria Graciela. University Of Michigan Medical School; Estados Unidos
dc.description.fil
Fil: Lowenstein, Pedro R.. University Of Michigan Medical School; Estados Unidos
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/protocol/10.1007%2F978-1-4939-2306-9_14
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-1-4939-2306-9_14
dc.conicet.paginas
354
dc.source.titulo
Gene Delivery and Therapy for Neurological Disorders
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