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dc.contributor.author
Juiz, Natalia Anahí
dc.contributor.author
Estupiñán, Elkyn
dc.contributor.author
Hernández, Daniel
dc.contributor.author
Garcilazo, Alejandra
dc.contributor.author
Chadi, Raúl
dc.contributor.author
Morales Sanfurgo, Gisela
dc.contributor.author
Schijman, Alejandro Gabriel
dc.contributor.author
Longhi, Silvia Andrea
dc.contributor.author
González, Clara Isabel
dc.date.available
2020-05-15T20:06:57Z
dc.date.issued
2019-01-16
dc.identifier.citation
Juiz, Natalia Anahí; Estupiñán, Elkyn; Hernández, Daniel; Garcilazo, Alejandra; Chadi, Raúl; et al.; Association study between CCR2-CCR5 genes polymorphisms and chronic Chagas heart disease in Wichi and in admixed populations from Argentina; Public Library of Science; Neglected Tropical Diseases; 13; 1; 16-1-2019; 1-12
dc.identifier.issn
1935-2727
dc.identifier.uri
http://hdl.handle.net/11336/105278
dc.description.abstract
Several studies have proposed different genetic markers of susceptibility to develop chronic Chagas cardiomyopathy (CCC). Many genes may be involved, each one making a small contribution. For this reason, an appropriate approach for this problematic is to study a large number of single nucleotide polymorphisms (SNPs) in individuals sharing a genetic background. Our aim was to analyze two CCR2 and seven CCR5 SNPs and their association to CCC in Argentina. A case-control study was carried out in 480 T. cruzi seropositive adults from Argentinean Gran Chaco endemic region (Wichi and Creole) and patients from Buenos Aires health centres. They were classified according to the Consensus on Chagas-Mazza Disease as non-demonstrated (non-DC group) or demonstrated (DC group) cardiomyopathy, i.e. asymptomatic or with CCC patients, respectively. Since, after allelic analysis, 2 out of 9 studied SNPs did not fit Hardy-Weinberg equilibrium in the unaffected non-DC group from Wichi patients, we analyzed them as a separate population. Only rs1800024T and rs41469351T in CCR5 gene showed significant differences within non-Wichi population (Creole + patients from Buenos Aires centres), being the former associated to protection, and the latter to risk of CCC. No evidence of association was observed between any of the analyzed CCR2-CCR5 gene polymorphisms and the development of CCC; however, the HHE haplotype was associated with protection in Wichi population. Our findings support the hypothesis that CCR2-CCR5 genes and their haplotypes are associated with CCC; however, depending on the population studied, different associations can be found. Therefore, the evolutionary context, in which the genes or haplotypes are associated with diseases, acquires special relevance.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Public Library of Science
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
CCR2-CCR5 GENES POLYMORPHISMS
dc.subject
CHRONIC CHAGAS HEART DISEASE
dc.subject.classification
Inmunología
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Association study between CCR2-CCR5 genes polymorphisms and chronic Chagas heart disease in Wichi and in admixed populations from Argentina
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-23T19:24:57Z
dc.identifier.eissn
1935-2735
dc.journal.volume
13
dc.journal.number
1
dc.journal.pagination
1-12
dc.journal.pais
Estados Unidos
dc.journal.ciudad
San Francisco
dc.description.fil
Fil: Juiz, Natalia Anahí. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Estupiñán, Elkyn. Universidad Industrial Santander; Colombia
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Fil: Hernández, Daniel. Universidad Nacional del Nordeste; Argentina
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Fil: Garcilazo, Alejandra. Hospital Pirovano; Argentina
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Fil: Chadi, Raúl. Hospital Pirovano; Argentina
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Fil: Morales Sanfurgo, Gisela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos "Ramos Mejía"; Argentina
dc.description.fil
Fil: Schijman, Alejandro Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: Longhi, Silvia Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones en Ingeniería Genética y Biología Molecular "Dr. Héctor N. Torres"; Argentina
dc.description.fil
Fil: González, Clara Isabel. Universidad Industrial de Santander; Colombia
dc.journal.title
Neglected Tropical Diseases
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1371/journal.pntd.0007033
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0007033
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6334923/
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