Mostrar el registro sencillo del ítem
dc.contributor.author
Barros, S. S.
dc.contributor.author
Gimeno, Eduardo Juan
dc.date.available
2020-05-14T17:11:04Z
dc.date.issued
2000-11
dc.identifier.citation
Barros, S. S.; Gimeno, Eduardo Juan; Cell Differentiation and Bone Protein Synthesis in the Lungs of Sheep with Spontaneous Calcinosis; Elsevier; Journal Of Comparative Pathology; 123; 4; 11-2000; 270-277
dc.identifier.issn
0021-9975
dc.identifier.uri
http://hdl.handle.net/11336/105132
dc.description.abstract
The lungs of three sheep with spontaneous enzootic calcinosis induced by the calcinogenic plantNierembergia veitchii (Nv) were examined electron microscopically and immunohistochemically. The main ultrastructural changes were activation of fibroblasts and modified smooth muscle cells (SMCs) in the pulmonary interstitium, with an increase in extracellular matrix and precipitation of calcium, either in a laminated pattern or as amorphous aggregates. Macrophages and multinucleated giant cells, some with calcium crystals in the cytoplasm, were found in areas of increased extracellular matrix. Thickening and replication of the basal lamina of capillaries were prominent. The bone proteins osteocalcin, osteopontin and osteonectin were detected immunohistochemically in the cytoplasm of activated fibroblasts, in modified SMCs and in the extracellular matrix. It is suggested that 1,25-dihydroxyvitamin D3in Nv induces cellular differentiation and the synthesis of a calcifiable matrix.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Nierembergia veitchii (Nv)
dc.subject
extracellular matrix.
dc.subject
1,25-dihydroxyvitamin D(3)
dc.subject
cellular differentiation
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Cell Differentiation and Bone Protein Synthesis in the Lungs of Sheep with Spontaneous Calcinosis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-11T15:16:24Z
dc.journal.volume
123
dc.journal.number
4
dc.journal.pagination
270-277
dc.journal.pais
Países Bajos
dc.journal.ciudad
Amsterdam
dc.description.fil
Fil: Barros, S. S.. Universidade Federal de Pelotas; Brasil
dc.description.fil
Fil: Gimeno, Eduardo Juan. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentina
dc.journal.title
Journal Of Comparative Pathology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0021997500904158
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1053/jcpa.2000.0415
Archivos asociados