Artículo
Endoplasmic Reticulum Stress in Tauopathies: Contrasting Human Brain Pathology with Cellular and Animal Models
Bocai, Nadia Irina
; Marcora, Maria Silvina
; Belfiori Carrasco, Lautaro Francisco
; Morelli, Laura
; Castaño, Eduardo Miguel
Fecha de publicación:
02/2019
Editorial:
IOS Press
Revista:
Journal of Alzheimer's Disease
ISSN:
1387-2877
e-ISSN:
1875-8908
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The accumulation and spreading of protein tau in the human brain are major features of neurodegenerative disorders known as tauopathies. In addition to several subcellular abnormalities, tau aggregation within neurons seems capable of triggering endoplasmic reticulum (ER) stress and the consequent unfolded protein response (UPR). In metazoans, full activation of a complex ER-UPR network may restore proteostasis and ER function or, if stress cannot be solved, commit cells to apoptosis. Due to these alternative outcomes (survival or death), the pharmacological manipulation of ER-UPR has become the focus of potential therapies in many human diseases, including tauopathies. Here we update and analyze the experimental data from human brain, cellular, and animal models linking tau accumulation and ER-UPR. We further discuss mechanistic aspects and put the ER-UPR into perspective as a possible therapeutic target in this group of diseases.
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Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Bocai, Nadia Irina; Marcora, Maria Silvina; Belfiori Carrasco, Lautaro Francisco; Morelli, Laura; Castaño, Eduardo Miguel; Endoplasmic Reticulum Stress in Tauopathies: Contrasting Human Brain Pathology with Cellular and Animal Models; IOS Press; Journal of Alzheimer's Disease; 68; 2; 2-2019; 439-458
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