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dc.contributor.author
Nair, Manoj Kumar Mohan
dc.contributor.author
De Masi, Leon
dc.contributor.author
Yue, Ming
dc.contributor.author
Galvan, Estela Maria
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dc.contributor.author
Chen, Huaiqing
dc.contributor.author
Wang, Fang
dc.contributor.author
Schifferli, Dieter M.
dc.date.available
2016-12-28T17:31:52Z
dc.date.issued
2015-05
dc.identifier.citation
Nair, Manoj Kumar Mohan; De Masi, Leon; Yue, Ming; Galvan, Estela Maria; Chen, Huaiqing; et al.; Adhesive properties of YapV and paralogous autotransporter proteins of Yersinia pestis; American Society For Microbiology; Infection And Immunity; 83; 5; 5-2015; 1809-1819
dc.identifier.issn
0019-9567
dc.identifier.uri
http://hdl.handle.net/11336/10500
dc.description.abstract
Yersinia pestis is the causative agent of plague. This bacterium evolved from an ancestral enteroinvasive Yersinia pseudotuberculosis strain by gene loss and acquisition of new genes, allowing it to use fleas as transmission vectors. Infection frequently leads to a rapidly lethal outcome in humans, a variety of rodents, and cats. This study focuses on the Y. pestis KIM yapV gene and its product, recognized as an autotransporter protein by its typical sequence, outer membrane localization, and amino-terminal surface exposure. Comparison of Yersinia genomes revealed that DNA encoding YapV or each of three individual paralogous proteins (YapK, YapJ, and YapX) was present as a gene or pseudogene in a strain-specific manner and only in Y. pestis and Y. pseudotuberculosis. YapV acted as an adhesin for alveolar epithelial cells and specific extracellular matrix (ECM) proteins, as shown with recombinant Escherichia coli, Y. pestis, or purified passenger domains. Like YapV, YapK and YapJ demonstrated adhesive properties, suggesting that their previously related in vivo activity is due to their capacity to modulate binding properties of Y. pestis in its hosts, in conjunction with other adhesins. A differential host-specific type of binding to ECM proteins by YapV, YapK, and YapJ suggested that these proteins participate in broadening the host range of Y. pestis. A phylogenic tree including 36 Y. pestis strains highlighted an association between the gene profile for the four paralogous proteins and the geographic location of the corresponding isolated strains, suggesting an evolutionary adaption of Y. pestis to specific local animal hosts or reservoirs.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
American Society For Microbiology
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dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Yersinia Pestis
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Autotransporter Proteins
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Adhesion
dc.subject.classification
Biología Celular, Microbiología
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dc.subject.classification
Ciencias Biológicas
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dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
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dc.title
Adhesive properties of YapV and paralogous autotransporter proteins of Yersinia pestis
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-16T17:25:00Z
dc.journal.volume
83
dc.journal.number
5
dc.journal.pagination
1809-1819
dc.journal.pais
Estados Unidos
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dc.journal.ciudad
Washington
dc.description.fil
Fil: Nair, Manoj Kumar Mohan. University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: De Masi, Leon. University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Yue, Ming. University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Galvan, Estela Maria. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. State University Of Pennsylvania; Estados Unidos
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Fil: Chen, Huaiqing. University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Wang, Fang. University Of Pennsylvania; Estados Unidos
dc.description.fil
Fil: Schifferli, Dieter M.. University Of Pennsylvania; Estados Unidos
dc.journal.title
Infection And Immunity
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://iai.asm.org/content/83/5/1809
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1128/IAI.00094-15
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