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dc.contributor.author
Solomon, Susan
dc.contributor.author
Pitossi, Fernando Juan
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dc.contributor.author
Rao, Mahendra S
dc.date.available
2016-12-28T17:21:37Z
dc.date.issued
2015-02
dc.identifier.citation
Solomon, Susan; Pitossi, Fernando Juan; Rao, Mahendra S; Banking on iPSC--is it doable and is it worthwhile; Humana Press; Stem Cell Reviews And Reports; 11; 1; 2-2015; 1-10
dc.identifier.issn
1550-8943
dc.identifier.uri
http://hdl.handle.net/11336/10492
dc.description.abstract
The discovery of induced pluripotent stem cells (iPSCs) and concurrent development of protocols for their cell-type specific differentiation have revolutionized studies of diseases and raised the possibility that personalized medicine may be achievable. Realizing the full potential of iPSC will require addressing the challenges inherent in obtaining appropriate cells for millions of individuals while meeting the regulatory requirements of delivering therapy and keeping costs affordable. Critical to making PSC based cell therapy widely accessible is determining which mode of cell collection, storage and distribution, will work. In this manuscript we suggest that moderate sized bank where a diverse set of lines carrying different combinations of commonly present HLA alleles are banked and differentiated cells are made available to matched recipients as need dictates may be a solution. We discuss the issues related to developing such a bank and how it could be constructed and propose a bank of selected HLA phenotypes from carefully screened healthy individuals as a solution to delivering personalized medicine.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Humana Press
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Ips
dc.subject
Reprogramación
dc.subject
Banco
dc.subject.classification
Neurociencias
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dc.subject.classification
Medicina Básica
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dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD
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dc.title
Banking on iPSC--is it doable and is it worthwhile
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-16T17:25:20Z
dc.journal.volume
11
dc.journal.number
1
dc.journal.pagination
1-10
dc.journal.pais
Estados Unidos
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dc.description.fil
Fil: Solomon, Susan. New York Stem Cell Foundation; Estados Unidos
dc.description.fil
Fil: Pitossi, Fernando Juan. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina
dc.description.fil
Fil: Rao, Mahendra S. National Institutes Of Health. National Cancer Institute; Estados Unidos
dc.journal.title
Stem Cell Reviews And Reports
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dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://link.springer.com/article/10.1007%2Fs12015-014-9574-4
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s12015-014-9574-4
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