Capítulo de Libro
Gene Therapy for the Treatment of Neurological Disorders : Central Nervous System Neoplasms
Título del libro: Gene Therapy for Neurological Disorders : Methods and Protocols
Kamran, Neha; Candolfi, Marianela
; Baker, Gregory J.; Moreno Ayala, Mariela Alejandra
; Dzaman, Marta; Lowenstein, Pedro R.; Castro, Maria Graciela
![Icon](/themes/CONICETDigital/images/conicet.png)
![Icon](/themes/CONICETDigital/images/conicet.png)
Otros responsables:
Manfredsson, Fredric P.
Fecha de publicación:
2016
Editorial:
Springer
ISBN:
978-1-4939-3270-2
Idioma:
Inglés
Clasificación temática:
Resumen
Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults with a median survival of 16.2–21.2 months post diagnosis (Stupp et al., N Engl J Med 352(10): 987–996, 2005). Because of its location, complete surgical resection is impossible; additionally because GBM is also resistant to chemotherapeutic and radiotherapy approaches, development of novel therapies is urgently needed. In this chapter we describe the development of preclinical animal models and a conditionally cytotoxic and immune-stimulatory gene therapy strategy that successfully causes tumor regression in several rodent GBM models.
Palabras clave:
GBM MODELS
,
IMMUNOTHERAPY
,
ADENOVIRAL GENE THERAPY
,
T CELL FUNCTION ASSAY
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Capítulos de libros(INBIOMED)
Capítulos de libros de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Capítulos de libros de INSTITUTO DE INVESTIGACIONES BIOMEDICAS
Citación
Kamran, Neha; Candolfi, Marianela; Baker, Gregory J.; Moreno Ayala, Mariela Alejandra; Dzaman, Marta; et al.; Gene Therapy for the Treatment of Neurological Disorders : Central Nervous System Neoplasms; Springer; 1382; 2016; 467-482
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