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Artículo

Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease

Martino Adami, Pamela VictoriaIcon ; Quijano, Cecilia; Magnani, Natalia DanielaIcon ; Galeano, PabloIcon ; Evelson, Pablo AndresIcon ; Cassina, Adriana; Do Carmo, Sonia; Leal, Maria CelesteIcon ; Castaño, Eduardo MiguelIcon ; Cuello, Claudio; Morelli, LauraIcon
Fecha de publicación: 11/2015
Editorial: Sage Publications
Revista: Journal Of Cerebral Blood Flow And Metabolism
ISSN: 0271-678X
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Neurociencias

Resumen

Synaptic bioenergetic deficiencies may be associated with early Alzheimer's disease (AD). To explore this concept, we assessed pre-synaptic mitochondrial function in hemizygous (+/-)TgMcGill-R-Thy1-APP rats. The low burden of Aβ and the wide array of behavioral and cognitive impairments described in 6-month-old hemizygous TgMcGill-R-Thy1-APP rats (Tg(+/-)) support their use to investigate synaptic bioenergetics deficiencies described in subjects with early Alzheimer's disease (AD). In this report, we show that pre-synaptic mitochondria from Tg(+/-) rats evidence a decreased respiratory control ratio and spare respiratory capacity associated with deficits in complex I enzymatic activity. Cognitive impairments were prevented and bioenergetic deficits partially reversed when Tg(+/-) rats were fed a nutritionally complete diet from weaning to 6-month-old supplemented with pyrroloquinoline quinone, a mitochondrial biogenesis stimulator with antioxidant and neuroprotective effects. These results provide evidence that, as described in AD brain and not proven in Tg mice models with AD-like phenotype, the mitochondrial bioenergetic capacity of synaptosomes is not conserved in the Tg(+/-) rats. This animal model may be suitable for understanding the basic biochemical mechanisms involved in early AD
Palabras clave: Amyloid Beta , Early-Alzheimer , Hippocampal Bioenergetics Status , Synaptosomes
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/10486
URL: http://journals.sagepub.com/doi/full/10.1177/0271678X15615132
DOI: http://dx.doi.org/10.1177/0271678X15615132
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Articulos(IIBBA)
Articulos de INST.DE INVEST.BIOQUIMICAS DE BS.AS(I)
Citación
Martino Adami, Pamela Victoria; Quijano, Cecilia; Magnani, Natalia Daniela; Galeano, Pablo; Evelson, Pablo Andres; et al.; Synaptosomal bioenergetic defects are associated with cognitive impairment in a transgenic rat model of early Alzheimer's disease; Sage Publications; Journal Of Cerebral Blood Flow And Metabolism; 37; 1; 11-2015; 69-84
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