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dc.contributor.author
Baoliang, Pan
dc.contributor.author
Yuwan, Wang
dc.contributor.author
Zhende, Pan
dc.contributor.author
Lifschitz, Adrian Luis
dc.contributor.author
Ming, Wang
dc.date.available
2020-05-11T14:53:07Z
dc.date.issued
2006-04
dc.identifier.citation
Baoliang, Pan; Yuwan, Wang; Zhende, Pan; Lifschitz, Adrian Luis; Ming, Wang; Pharmacokinetics of Eprinomectin in Plasma and Milk following Subcutaneous Administration to Lactating Dairy Cattle; Springer; Veterinary Research Communications; 30; 3; 4-2006; 263-270
dc.identifier.issn
0165-7380
dc.identifier.uri
http://hdl.handle.net/11336/104749
dc.description.abstract
Eprinomectin is only available as a topically applied anthelmintic for dairy cattle. To determine whether eprinomectin can be applied as an injectable formulation in dairy cattle, a novel injectable formulation was developed and was subcutaneously delivered to four lactating dairy cattle at a dose rate of 0.2 mg/ kg. Plasma and milk samples were collected. The concentrations of eprinomectin in all samples were determined by HPLC. The peak plasma concentration (Cmax)of 44.0±24.2 ng/ml occurred 39±19.3 h after subcutaneous administration, equivalent to the Cmax (43.76±18.23 ng/ml) previously reported for dairy cattle after a pour-on administration of 0.5 mg/kg eprinomectin. The area under the plasma concentration–time curve (AUC) after subcutaneous administration was 7354±1861 (ng h)/ml, higher than that obtained after pour-on delivery (5737.68±412.80 (ng h)/ml). The mean residence time (MRT) of the drug in plasma was 211±55.2 h. Eprinomectin was detected in the milk at the second sampling time. The concentration of drug in milk was parallel to that in plasma, with a milk to plasma ratio of 0.16±0.01. The highest detected concentration of eprinomectin in milk was 9.0 ng/ml, below the maximum residue limit (MRL) of eprinomectin in milk established by the Joint FAO/WHO Expert Committee on Food Additives in 2000. The amount of eprinomectin recovered in the milk during this trial was 0.39%±0.08% of the total administered dose. This study demonstrates that subcutaneous administration of eprinomectin led to higher bioavailability and a lower dose than a pour-on application, and that an injectable formulation of eprinomectin may be applied in dairy cattle with a zero withdrawal period.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
EPRINOMECTIN
dc.subject
INJECTABLE FORMULATION
dc.subject
PHARMACOKINETICS
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
Ciencias Veterinarias
dc.subject.classification
CIENCIAS AGRÍCOLAS
dc.title
Pharmacokinetics of Eprinomectin in Plasma and Milk following Subcutaneous Administration to Lactating Dairy Cattle
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-05-05T16:05:17Z
dc.identifier.eissn
1573-7446
dc.journal.volume
30
dc.journal.number
3
dc.journal.pagination
263-270
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Baoliang, Pan. China Agricultural University. College of Veterinary Medicine; República de China
dc.description.fil
Fil: Yuwan, Wang. Beijing China Agricultural University; República de China. Biological Technique Limited Corporation; República de China
dc.description.fil
Fil: Zhende, Pan. Beijing China Agricultural University; República de China. Biological Technique Limited Corporation; República de China
dc.description.fil
Fil: Lifschitz, Adrian Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
dc.description.fil
Fil: Ming, Wang. China Agricultural University. College of Veterinary Medicine; República de China
dc.journal.title
Veterinary Research Communications
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/s11259-006-3230-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s11259-006-3230-7
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