Artículo
Orthohantavirus genotype Lechiguanas in Oligoryzomys nigripes (Rodentia: Cricetidae): New evidence of host-switching
Colombo, Valeria Carolina
; Brignone, Juan Jeronimo; Sen, Carina; Previtali, Maria Andrea
; Martin, María Laura
; Levis, Silvana del Carmen; Monje, Lucas Daniel
; González Ittig, Raúl Enrique
; Beldomenico, Pablo Martín
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Fecha de publicación:
03/2019
Editorial:
Elsevier Science
Revista:
Acta Tropica
ISSN:
0001-706X
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
To identify and predict situations of increased risk of orthohantavirus infection in humans, it is necessary to study the relationships between the virus and its rodent hosts. The present study investigated orthohantavirus infection in an assemblage of wild Sigmodontinae rodents of the Paraná Delta, Argentina, and providing new evidence of host-switching events. Rodents belonging to the species Oxymycterus rufus (n=187), Akodon azarae (n=82), Oligoryzomys flavescens (n=80), Oligoryzomys nigripes (n=47), Scapteromys aquaticus (n=38), Deltamys kempi (n=7) and Holochilus brasiliensis (n=2) were captured at 4 sampling sites during 20 trapping sessions. Blood sampleswere analyzed by IgG ELISA and livers by a nested reverse transcription PCR for the diagnosis of orthohantavirus infection. The amplified products of the S and M orthohantavirus genomes were sequenced and analyzed to determine similarities with species of the Orthohantavirus genus. The species of the Oligoryzomys positive to the virus were confirmed by amplifying and sequencing thecomplete cyt b gene. Of the 443 serum samples analyzed by IgG ELISA, A. azarae presented the highest host-specific prevalence value (10/82, 12.2%) followed by Ol. nigripes (4/47, 8.5 %) and Ox. rufus (1/187, 0.5%). All the sero-positive Ol. nigripes (n= 4) were positive to the amplification of the S and M segments of the Lechiguanas genotype (98% nucleotide identity for both segments).This is surprising given that Ol. nigripes has been previously associated with Juquitiba genotype, not Lechiguanas. The latter is generally associated with Ol. flavescens, which in our study were all sero-negative. In addition, the association Ox. rufus ? Pergamino genotype found here is, to ourknowledge, novel and another potential evidence of host-switching considering that Pergamino has been originally associated with A. azarae. These findings contribute to the building evidence that contradicts the one-genotype-one-reservoir species premise in the association betweenrodent reservoirs and orthohantaviruses, and supports the hypothesis that the community structure of sympatric host species may contribute to orthohantavirus dynamics.
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Articulos(CCT - SANTA FE)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - SANTA FE
Articulos(ICIVET-LITORAL)
Articulos de INST. DE CIENCIAS VETERINARIAS DEL LITORAL
Articulos de INST. DE CIENCIAS VETERINARIAS DEL LITORAL
Articulos(IDEA)
Articulos de INSTITUTO DE DIVERSIDAD Y ECOLOGIA ANIMAL
Articulos de INSTITUTO DE DIVERSIDAD Y ECOLOGIA ANIMAL
Citación
Colombo, Valeria Carolina; Brignone, Juan Jeronimo; Sen, Carina; Previtali, Maria Andrea; Martin, María Laura; et al.; Orthohantavirus genotype Lechiguanas in Oligoryzomys nigripes (Rodentia: Cricetidae): New evidence of host-switching; Elsevier Science; Acta Tropica; 191; 3-2019; 133-138
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