Artículo

Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides

Sasiambarrena, Leandro DanielIcon ; Barrios, Ivan A.; Fraga, Guido G.; Bravo, Rodolfo Daniel; Ponzinibbio, AgustínIcon
Fecha de publicación: 01/2019
Editorial: Pergamon-Elsevier Science Ltd
Revista: Tetrahedron Letters
ISSN: 0040-4039
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:

Resumen

A facile and efficient method was developed for the synthesis of 1,2,4,5-tetrahydro-1,4-benzodiazepine-3-ones from 2-chloro-N-(2-nitrobenzyl)acetamides through a reductive cyclization using iron-ammonium chloride in ethanol?water in good yields. This method provides a simple approach to these benzodiazepine-3-ones which are of high value in the field of medicinal chemistry research.
Palabras clave: 1,4-BENZODIAZEPINES , 2-CHLORO-N-(2-NITROBENZYL)ACETAMIDES , IRON-AMMONIUM CHLORIDE REDUCTION , 2-NITROBENZYLAMINES
 
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/104501
URL: https://www.sciencedirect.com/science/article/pii/S0040403918314722
DOI: http://dx.doi.org/10.1016/j.tetlet.2018.12.029
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Articulos(CCT - LA PLATA)
Articulos de CTRO.CIENTIFICO TECNOL.CONICET - LA PLATA
Citación
Sasiambarrena, Leandro Daniel; Barrios, Ivan A.; Fraga, Guido G.; Bravo, Rodolfo Daniel; Ponzinibbio, Agustín; Facile synthesis of 4-substituted 1,2,4,5-tetrahydro-1,4-benzodiazepin-3-ones by reductive cyclization of 2-chloro-N-(2-nitrobenzyl)acetamides; Pergamon-Elsevier Science Ltd; Tetrahedron Letters; 60; 3; 1-2019; 264-267
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