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Artículo

Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease

Sookoian, Silvia CristinaIcon ; Castaño, Gustavo Osvaldo; Fernández Gianotti, TomásIcon ; Gemma, CarolinaIcon ; Rosselli, Maria SoledadIcon ; Pirola, Carlos JoséIcon
Fecha de publicación: 10/2008
Editorial: Academic Press Ltd - Elsevier Science Ltd
Revista: Cytokine
ISSN: 1043-4666
Idioma: Inglés
Tipo de recurso: Artículo publicado
Clasificación temática:
Bioquímica y Biología Molecular; Gastroenterología y Hepatología

Resumen

Aims: To investigate the role of gene variants and derived haplotypes of the STAT3 transcription factor in nonalcoholic fatty liver disease (NAFLD) and their relation with the clinical disease severity. Patients & Methods: 108 patients with NAFLD and different stages of clinical disease severity, and a group of 55 healthy individuals were included in a Hospital-based study. We selected 3 tagSNPs showing a minor allele frequency >10 % (rs2293152 C/G, rs6503695 C/T, and rs9891119 A/C) encompassing 68.55 kb in chromosome 17, representing 24 polymorphic sites (r2 >0.8). Results: In univariate analysis, there were significant differences in the allele frequency of the rs6503695 and rs9891119 between the healthy individuals and NAFLD patients (empiric P =0.021 and 0.020, respectively). The test results for the multi-marker analysis showed that haplotypes TA and CC of tagSNPs rs6503695, rs9891119 were significantly associated with NAFLD (empiric P = 0.035 and 0.015, respectively). When we tested the hypothesis of a relation between the gene variants and the clinical and histological spectrum of NAFLD by multinomial analysis, a significant association was observed with rs9891119 (P = 0.02). Conclusions: Our study suggests a potential role of the STAT3 polymorphisms and their haplotypes in susceptibility to NAFLD and disease severity.
Palabras clave: STAT3 , Gene variants , Fatty liver , NAFLD , Nonalcoholic steatohepatitis , NASH
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info:eu-repo/semantics/openAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/104395
URL: https://www.sciencedirect.com/science/article/abs/pii/S1043466608006819
DOI: https://doi.org/10.1016/j.cyto.2008.08.001
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Articulos(IDIM)
Articulos de INST.DE INVEST.MEDICAS
Citación
Sookoian, Silvia Cristina; Castaño, Gustavo Osvaldo; Fernández Gianotti, Tomás; Gemma, Carolina; Rosselli, Maria Soledad; et al.; Genetic variants in STAT3 are associated with nonalcoholic fatty liver disease; Academic Press Ltd - Elsevier Science Ltd; Cytokine; 44; 1; 10-2008; 201-206
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