Salicylate release from a polypyrrole matrix

Abstract

Salicylate release from a microstructured polypyrrole coating with a large surface area was investigated. Thedrug was incorporated as a dopant in the polymer matrix via electropolymerization of pyrrole in a simple one-step process. The influence of several parameters such as applied potential and hydrodynamic conditions on thereleasing behavior was studied. Once the drug has been delivered from the polymeric matrix, the electrode canbe reloaded with salicylate for later release. The amount of eluted salicylate was effective in inhibiting albumindenaturation which is associated with antiinflammatory effects.