Artículo
Molecular characterization of hepatitis C virus genotype 4 sequences in HIV-coinfected patients from Argentina
Fecha de publicación:
06/12/2011
Editorial:
Wiley-liss, Div John Wiley & Sons Inc
Revista:
Journal of Medical Virology
ISSN:
0146-6615
Idioma:
Inglés
Tipo de recurso:
Artículo publicado
Clasificación temática:
Resumen
The prevalence of hepatitis C virus genotype 4 (HCV-4) is increasing in different parts of the World but in Latin America the data are still scarce. We aimed to characterize HCV-4 isolates from 383 HIV-coinfected patients in Argentina. Sequence analyses were based on the non-structural 5B region of HCV. Results from 18 patients indicated a genetic heterogeneity that involved three genotype 4 subtypes. Sequences were ascribed to subtype 4d (67%), 4a (22%) and 4m (11%). In spite of different sources of transmission were defined among patients, no statistical association was found with the genotype 4 subtype. The scenario is also compatible with multiple importation of the epidemic and there is no evidence for transmission–specific clusters or network-like transmission of HCV-4. This HCV-4 does not represent a recent introduction in Argentina, it circulates in all transmission groups and its presence is increasing among HIV-infected patients.
Palabras clave:
HCV
,
phylogenetic
,
genotype 4
Archivos asociados
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Identificadores
Colecciones
Articulos(INBIRS)
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Articulos de INSTITUTO DE INVESTIGACIONES BIOMEDICAS EN RETROVIRUS Y SIDA
Articulos(OCA HOUSSAY)
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos de OFICINA DE COORDINACION ADMINISTRATIVA HOUSSAY
Articulos(SEDE CENTRAL)
Articulos de SEDE CENTRAL
Articulos de SEDE CENTRAL
Citación
Bolcic, Federico Martin; Jones, Leandro Roberto; Laufer, Natalia Lorna; Quarleri, Jorge Fabian; Molecular characterization of hepatitis C virus genotype 4 sequences in HIV-coinfected patients from Argentina; Wiley-liss, Div John Wiley & Sons Inc; Journal of Medical Virology; 83; 6; 6-12-2011; 935-940
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