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dc.contributor.author
Levental, Kandice R.  
dc.contributor.author
Yu, Hongmei  
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Kass, Laura  
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Lakins, Johnathon N.  
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Egeblad, Mikala  
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Erler, Janine T.  
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Fong, Sheri F.T.  
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Csiszar, Katalin  
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Giaccia, Amato  
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Weninger, Wolfgang  
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Yamauchi, Mitsuo  
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Gasser, David L.  
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Weaver, Valerie M.  
dc.date.available
2020-05-01T20:27:56Z  
dc.date.issued
2009-11  
dc.identifier.citation
Levental, Kandice R.; Yu, Hongmei; Kass, Laura; Lakins, Johnathon N.; Egeblad, Mikala; et al.; Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling; Cell Press; Cell; 139; 5; 11-2009; 891-906  
dc.identifier.issn
0092-8674  
dc.identifier.uri
http://hdl.handle.net/11336/104074  
dc.description.abstract
Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found that breast tumorigenesis is accompanied by collagen crosslinking, ECM stiffening, and increased focal adhesions. Induction of collagen crosslinking stiffened the ECM, promoted focal adhesions, enhanced PI3 kinase (PI3K) activity, and induced the invasion of an oncogene-initiated epithelium. Inhibition of integrin signaling repressed the invasion of a premalignant epithelium into a stiffened, crosslinked ECM and forced integrin clustering promoted focal adhesions, enhanced PI3K signaling, and induced the invasion of a premalignant epithelium. Consistently, reduction of lysyl oxidase-mediated collagen crosslinking prevented MMTV-Neu-induced fibrosis, decreased focal adhesions and PI3K activity, impeded malignancy, and lowered tumor incidence. These data show how collagen crosslinking can modulate tissue fibrosis and stiffness to force focal adhesions, growth factor signaling and breast malignancy.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Cell Press  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
MATRIX CROSSLINKING  
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INTEGRIN SIGNALING  
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MECHANICAL FORCE  
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MAMMARY GLAND  
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Otras Ciencias Biológicas  
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Ciencias Biológicas  
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CIENCIAS NATURALES Y EXACTAS  
dc.title
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling  
dc.type
info:eu-repo/semantics/article  
dc.type
info:ar-repo/semantics/artículo  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.date.updated
2020-04-28T13:09:46Z  
dc.journal.volume
139  
dc.journal.number
5  
dc.journal.pagination
891-906  
dc.journal.pais
Estados Unidos  
dc.description.fil
Fil: Levental, Kandice R.. State University of Pennsylvania; Estados Unidos  
dc.description.fil
Fil: Yu, Hongmei. University of California; Estados Unidos  
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Fil: Kass, Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Salud y Ambiente del Litoral. Universidad Nacional del Litoral. Instituto de Salud y Ambiente del Litoral; Argentina  
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Fil: Lakins, Johnathon N.. University of California; Estados Unidos  
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Fil: Egeblad, Mikala. University of California; Estados Unidos  
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Fil: Erler, Janine T.. Stanford University School of Medicine; Estados Unidos  
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Fil: Fong, Sheri F.T.. University of Hawaii at Manoa; Estados Unidos  
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Fil: Csiszar, Katalin. University of Hawaii at Manoa; Estados Unidos  
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Fil: Giaccia, Amato. Stanford University School of Medicine; Estados Unidos  
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Fil: Weninger, Wolfgang. Wistar Institute; Estados Unidos  
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Fil: Yamauchi, Mitsuo. University of North Carolina; Estados Unidos  
dc.description.fil
Fil: Gasser, David L.. State University of Pennsylvania; Estados Unidos  
dc.description.fil
Fil: Weaver, Valerie M.. State University of Pennsylvania; Estados Unidos  
dc.journal.title
Cell  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.cell.2009.10.027