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dc.contributor.author
Rogan, Dragan
dc.contributor.author
Fumuso, Elida Ana
dc.contributor.author
Rodriguez, Edgardo Mario
dc.contributor.author
Wade, Jos
dc.contributor.author
Sanchez Bruni, Sergio Fabian
dc.date.available
2020-04-30T17:42:51Z
dc.date.issued
2007-03
dc.identifier.citation
Rogan, Dragan; Fumuso, Elida Ana; Rodriguez, Edgardo Mario; Wade, Jos; Sanchez Bruni, Sergio Fabian; Immunomodulation with a Mycobacterial Cell Wall Extract (MCWE) in susceptible mares to clear experimentally induced endometritis with Streptococcus zooepidemicus; Elsevier Science Inc; Journal of Equine Veterinary Science; 27; 3; 3-2007; 112-117
dc.identifier.issn
0737-0806
dc.identifier.uri
http://hdl.handle.net/11336/104023
dc.description.abstract
The ability of an immunomodulator, mycobacterial cell wall extract (MCWE), to clear uterine infection in susceptible mares after an experimental challenge with Streptococcus zooepidemicus was evaluated. Thirty mares susceptible to endometritis, based on the presence of uterine fluid during both diestrus and estrus, were selected from a herd of 896 and inoculated with a live culture of 5 × 106 CFU of S. zooepidemicus on day 1 of estrus. Twenty-four hours later, mares were evaluated by ultrasonography, bacteriology, exfoliative cytology, and uterine biopsy to confirm infection. Forty-eight hours after inoculation, and on confirmation of uterine infection, mares were randomly assigned to one of four unbalanced experimental treatments to receive 1500 μg MCWE IU (n = 10) or IV (n = 10), or placebo IU (n = 5) or IV (n = 5). Mares were examined at ovulation and 7 days post-ovulation for uterine fluid via transrectal ultrasonography and for bacteriology, exfoliative cytology, and uterine biopsy. Efficacy was based on the ability of the mare to clear endometritis as determined by negative bacteriology and reduced numbers of polymorphonuclear cells (PMNs) on uterine biopsy. Because no statistical difference was detected between routes of administration on day 7 post-ovulation, the data sets were combined and re-analyzed to evaluate overall efficacy. Endometritis was observed in all placebo-treated mares 7 days post-ovulation, whereas treatment with MCWE resulted in the elimination of endometritis in 35% of the mares by the time of ovulation, and 70% of the mares by 7 days post-ovulation. Treatment with MCWE, compared with the placebo group, resulted in a significant decrease in the number of mares positive for endometritis at ovulation based on exfoliative cytology and bacteriology (P < .01) and at 7 days post-ovulation based on biopsy, exfoliative cytology, and bacteriology (P < .001). Results indicate that MCWE was an effective treatment for the elimination of endometritis caused by S. zooepidemicus in mares.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier Science Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
MARES
dc.subject
ENDOMETRITIS
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INNATE IMMUNITY
dc.subject
MYCOBACTERIAL CELL WALL EXTRACT (MCWE)
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Otras Ciencias Veterinarias
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Ciencias Veterinarias
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CIENCIAS AGRÍCOLAS
dc.title
Immunomodulation with a Mycobacterial Cell Wall Extract (MCWE) in susceptible mares to clear experimentally induced endometritis with Streptococcus zooepidemicus
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-17T14:38:56Z
dc.identifier.eissn
1542-7412
dc.journal.volume
27
dc.journal.number
3
dc.journal.pagination
112-117
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Rogan, Dragan. Bioniche Animal Health; Canadá
dc.description.fil
Fil: Fumuso, Elida Ana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Rodriguez, Edgardo Mario. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.description.fil
Fil: Wade, Jos. Bioniche Animal Health; Irlanda
dc.description.fil
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
dc.journal.title
Journal of Equine Veterinary Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jevs.2007.01.010
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0737080607000494
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