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dc.contributor.author
Campaña, Hebe
dc.contributor.author
Rittler, Monica
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Poletta, Fernando Adrián
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Gili, Juan Antonio
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Pawluk, Mariela Soledad
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Scala, Sandra Constanza
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Camelo, Jorge Santiago López
dc.date.available
2020-04-28T21:00:58Z
dc.date.issued
2013-06
dc.identifier.citation
Campaña, Hebe; Rittler, Monica; Poletta, Fernando Adrián; Gili, Juan Antonio; Pawluk, Mariela Soledad; et al.; Minor Anomalies: Can They Predict Specific Major Defects? A Study Based on 23 Major and 14 Minor Anomalies in Over 25,000 Newborns with Birth Defects; Thieme Medical Publ Inc; American Journal of Perinatology; 31; 6; 6-2013; 447-454
dc.identifier.issn
0735-1631
dc.identifier.uri
http://hdl.handle.net/11336/103840
dc.description.abstract
Background Minor anomalies (mAs) are morphological features with little clinical relevance that have been mentioned as possible predictors of major defects (MDs). Objectives To identify the preferential associations between selected MDs and mAs and to establish if mAs can serve as predictors for specific MDs. Study Design Information of newborns with birth defects was obtained from the ECLAMC (Latin American Collaborative Study of Congenital Malformations) database. The sample consisted of 27,247 live- and stillborn newborns with multiple malformations that included at least one of the selected MDs or mAs. The odds ratio and predictive values were calculated for significant associations, and concurrence rates in first degree relatives. Results A total of 33 significant minor–major associations were identified. Single umbilical artery (SUA) and preauricular tags were the most frequent mAs; the former was associated with 10 MDs, the latter only with microtia. The highest positive predictive value was shown by SUA for anal atresia. Newborns with preauricular tags had significantly more relatives with microtia than expected. Conclusions No new relevant associations between MDs and mAs were identified and few mAs seem to serve as predictors for specific MDs in the same newborn. However, preauricular tags can predict the occurrence of microtia in other family members.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Thieme Medical Publ Inc
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Epidemiology
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minor anomalies
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predictors
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birth defects
dc.subject.classification
Epidemiología
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Ciencias de la Salud
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Minor Anomalies: Can They Predict Specific Major Defects? A Study Based on 23 Major and 14 Minor Anomalies in Over 25,000 Newborns with Birth Defects
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2020-04-28T14:09:10Z
dc.journal.volume
31
dc.journal.number
6
dc.journal.pagination
447-454
dc.journal.pais
Estados Unidos
dc.description.fil
Fil: Campaña, Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Rittler, Monica. Universidad de Buenos Aires; Argentina
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Fil: Poletta, Fernando Adrián. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Gili, Juan Antonio. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.description.fil
Fil: Pawluk, Mariela Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Scala, Sandra Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina
dc.description.fil
Fil: Camelo, Jorge Santiago López. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto Multidisciplinario de Biología Celular. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Instituto Multidisciplinario de Biología Celular. Universidad Nacional de La Plata. Instituto Multidisciplinario de Biología Celular; Argentina. Centro de Educación Médica e Investigaciones Clínicas "Norberto Quirno"; Argentina
dc.journal.title
American Journal of Perinatology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pubmed/23966126
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1055/s-0033-1351660