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dc.contributor.author
Buffone, Mariano Gabriel
dc.date.available
2020-04-28T12:15:47Z
dc.date.issued
2016
dc.identifier.citation
Buffone, Mariano Gabriel; Sperm acrosome biogenesis and function during fertilization; Springer-VERLAG BERLIN; 1; 2016; 172
dc.identifier.isbn
978-3-319-30567-7
dc.identifier.uri
http://hdl.handle.net/11336/103745
dc.description.abstract
Over the last decades, acrosomal exocytosis (also called the “acrosome reaction”) has been recognized as playing an essential role in fertilization. Secretion of this granule is an absolute requirement for physiological fertilization. In recent years, the study of mammalian acrosomal exocytosis has yielded some major advances that challenge the long-held, general paradigms in the field. Principally, the idea that sperm must be acrosome-intact to bind to the zona pellucida of unfertilized eggs, based largely on in vitro fertilization studies of mouse oocytes denuded of the cumulus oophorus, has been overturned by experiments using state-of-the-art imaging of cumulus-intact oocytes and fertilization experiments where eggs were reinseminated by acrosome-reacted sperm recovered from the perivitelline space of zygotes. From a molecular point of view, acrosome exocytosis is a synchronized and tightly regulated process mediated by molecular mechanisms that are homologous to those reported in neuroendocrinal cell secretions. The authors provide a broader perspective, focusing on a limited number of important topics that are essential for understanding the molecular mechanisms governing this step in the fertilization process. They also discuss molecular aspects such as the signaling pathways leading to exocytosis, including the participation of ion channels, lipids, the fusion machinery proteins and the actin cytoskeleton as well as cellular aspects such as the site of acrosomal exocytosis and the use of gene-manipulated animals to study this process.
Table of contents
Front Matter
Pages i-vii
The Acrosome Reaction: A Historical Perspective
Masaru Okabe
Pages 1-13
The Acrosomal Matrix
James A. Foster, George L. Gerton
Pages 15-33
Role of Ion Channels in the Sperm Acrosome Reaction
Carmen Beltrán, Claudia L. Treviño, Esperanza Mata-Martínez, Julio C. Chávez, Claudia Sánchez-Cárdenas, Mark Baker et al.
Pages 35-69
The Molecules of Sperm Exocytosis
Silvia A. Belmonte, Luis S. Mayorga, Claudia N. Tomes
Pages 71-92
Sperm Capacitation and Acrosome Reaction in Mammalian Sperm
Cintia Stival, Lis del C. Puga Molina, Bidur Paudel, Mariano G. Buffone, Pablo E. Visconti, Dario Krapf
Pages 93-106
Lipid Regulation of Acrosome Exocytosis
Roy Cohen, Chinatsu Mukai, Alexander J. Travis
Pages 107-127
Role of Actin Cytoskeleton During Mammalian Sperm Acrosomal Exocytosis
Ana Romarowski, Guillermina M. Luque, Florenza A. La Spina, Dario Krapf, Mariano G. Buffone
Pages 129-144
Site of Mammalian Sperm Acrosome Reaction
Noritaka Hirohashi
Pages 145-158
Acrosome Reaction as a Preparation for Gamete Fusion
Patricia S. Cuasnicú, Vanina G. Da Ros, Mariana Weigel Muñoz, Débora J. Cohen
Pages 159-172
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer-VERLAG BERLIN
dc.rights
info:eu-repo/semantics/closedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
SPERM
dc.subject
ACROSOME
dc.subject
FERTILIZATION
dc.subject
EXOCYTOSIS
dc.subject.classification
Biología Reproductiva
dc.subject.classification
Ciencias Biológicas
dc.subject.classification
CIENCIAS NATURALES Y EXACTAS
dc.title
Sperm acrosome biogenesis and function during fertilization
dc.type
info:eu-repo/semantics/publishedVersion
dc.type
info:eu-repo/semantics/book
dc.type
info:ar-repo/semantics/libro
dc.date.updated
2020-02-20T16:37:40Z
dc.journal.volume
1
dc.journal.pagination
172
dc.journal.pais
Alemania
dc.journal.ciudad
Frankfurt
dc.description.fil
Fil: Buffone, Mariano Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/isbn/978-3-319-30567-7
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1007/978-3-319-30567-7
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