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dc.contributor.author
Agotegaray, Mariela Alejandra
dc.contributor.author
Lassalle, Verónica Leticia
dc.date.available
2016-12-27T21:11:55Z
dc.date.issued
2014-07
dc.identifier.citation
Agotegaray, Mariela Alejandra; Lassalle, Verónica Leticia; Study of the Experimental Conditions and Mechanisms for Diclofenac Loading in Functionalized Magnetic Nanoparticles; Aarya Publishing House; International Journal of Chemical and Pharmaceutical Analysis; 1; 4; 7-2014; 154-164
dc.identifier.issn
2395 - 2466
dc.identifier.uri
http://hdl.handle.net/11336/10367
dc.description.abstract
Magnetic nanoparticles (MNPs) composed of magnetite coated with oleic acid and functionalized with chitosan have been prepared to the targeted release of the non steroidal anti-inflammatory drug (NSAID) Diclofenac. Two procedures to incorporate the drug were explored: simple adsorption and covalent linkage. The impact of experimental variables such as the nature of the NSAID (commercial versus analytical sodium Diclofenac), its concentration and amount of coupling agent were evaluated in terms of the loading efficiency and the properties of interest of MNPs (size, surface functionality, stability). Loaded and unloaded MNPs were characterized by FTIR-DRIFTS spectroscopy, dynamic light scattering, zeta potential and transmission electron microscopy. UV-visible quantification of Diclofenac was achieved reaching values of loading efficiency between 11 and 27% depending on the experimental conditions. Probable mechanisms for drug-MNPs interactions have been proposed on the base of characterization data. A nanocarrier of size lower than 150 nm, with satisfactory loading skill and high dispersion capability on water was obtained. The release behavior demonstrated to be independent on the presence of an external magnetic field. The properties found in these nanosystems result relevant in view of their effective in vivo implementation.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Aarya Publishing House
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
Magnetic Nanoparticles
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Chitosan
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Diclofenac
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Drug Target
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In Vitro Release
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Nano-materiales
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Nanotecnología
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INGENIERÍAS Y TECNOLOGÍAS
dc.title
Study of the Experimental Conditions and Mechanisms for Diclofenac Loading in Functionalized Magnetic Nanoparticles
dc.type
info:eu-repo/semantics/article
dc.type
info:ar-repo/semantics/artículo
dc.type
info:eu-repo/semantics/publishedVersion
dc.date.updated
2016-12-22T20:37:25Z
dc.identifier.eissn
2348-0726
dc.journal.volume
1
dc.journal.number
4
dc.journal.pagination
154-164
dc.journal.pais
India
dc.journal.ciudad
Maharashtra
dc.description.fil
Fil: Agotegaray, Mariela Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur; Argentina
dc.description.fil
Fil: Lassalle, Verónica Leticia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Bahía Blanca. Instituto de Química del Sur; Argentina. Universidad Nacional del Sur; Argentina
dc.journal.title
International Journal of Chemical and Pharmaceutical Analysis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/http://pmindexing.com/journals/index.php/IJCPA/article/view/288
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